Familial Mediterranean fever and prolonged febrile myalgia syndrome: Case report

Abstract

ÖZKarın ağrısı, çocuklarda sık görülen bir yakınmadır, cerrahi ve cerrahi dışı nedenleri mevcuttur. Ailesel Akdeniz ateşi, cerrahi dışı nedenler arasında yer almakta ve ateş yüksekliği, inflamatuar serozit ile seyretmektedir. Uzamış febril miyalji sendromu, Ailesel Akdeniz ateşi ile birlikte görülebilmektedir ve ilk kez 1994 yılında tanımlan-mıştır. Uzamış febril miyalji sendromunda yüksek ateş, miyalji, karın ağrısı, artrit/ artralji ve döküntüler görülebilmektedir. Bu makalede ateş yüksekliği ve karın ağrısı ile başvuran, takibinde eklenen kas ağrıları ile ilk atağı uzamış febril miyalji ve Ailesel Akdeniz ateşi tanısı alan bir olgu sunulmuştur. Uzamış febril miyalji sendromunun, Ailesel Akdeniz ateşinde atipik klinik belirtilerden biri olduğu ve ilk başvuruda görü-lebileceği vurgulanmak istenmiştir. Anahtar kelimeler: Ailesel Akdeniz ateşi, karın ağrısı, uzamış febril miyalji ABSTRACTAbdominal pain is a common complain in children which is caused by surgical and non-surgical reasons. Familial meditterian fever is one of the common non-surgical reasons and the most common syptoms are fever and inflammatory serositis. But one of the rare form is protracted febrile myalgia defined first time in 1944. This form may coexist with fever, myalgia, abdominal pain, athritis and athralgia. In this article, we presented a case with fever and abdominal pain, followed by muscular pain diagnosed as a protracted febrile myalgia syndrome and Familial Mediterranean Fever. It is emphasized that the prolonged febrile myalgia syndrome is one of the atypical clinical manifestations in the Familial Mediterranean Fever and may be seenat the first admission.

Protracted Febrile Myalgia Associated with Fever of Unknown Origin

“…Also abdominal pain with fever was seen prominently at the time of the attack than miyalgia in the literature. 2,7 Studies have indicated that PFMS is seen more frequently in patients with three mutations: M684V, V726A and E148Q. 8 Although our patient has three different variants in the MEFV gene, K569R has not been defined as a mutation for FMF yet (different from K695R).…”

“…Although FMF is in the list of FUO etiology, it is generally characterized by recurrent self-limiting episodes for 1-3 days of fever and painful polyserositis affecting mainly peritoneum, pleura, and synovium. 2,4 The clinical profile of FMF has been appreciably expanded in the last 10 years as additional features have been described, including PFMS. 4 The symptoms respond effectively to corticosteroids.…”

“…1 Although familial mediterranean fever (FMF) is generally characterized by episodic fever, protracted febrile myalgia syndrome (PFMS) may be seen as the presenting finding in patients with FMF and may be an etiologic factor for FUO as well. 2,3 The aim of reporting this case was to draw attention to the important characteristics of PFMS, which is an uncommon and severe manifestation of FMF.…”