Familial Liability for Eating Disorders and Suicide Attempts

Yao, Shuyang; Kuja‐Halkola, Ralf; Thornton, Laura M.; Runfola, Cristin D.; D’Onofrio, Brian M.; Almqvist, Catarina; Lichtenstein, Paul; Sjölander, Arvid; Larsson, Henrik; Bulik, Cynthia M.

doi:10.1001/jamapsychiatry.2015.2737

Cited by 85 publications

(107 citation statements)

References 33 publications

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“…When examining how BED and BN were uniquely associated with suicidality at the multivariate level, the association between BED and suicidality (i.e., suicide ideation, planning, and attempting) became non‐significant while the association between BN and suicidality (i.e., suicide ideation, planning, and attempting) remained significant among adolescents only. Overall, results are consistent with previous findings that EDs themselves and their frequently co‐occurring conditions contribute to suicide risk in EDs . For instance, the adolescent BN findings are consistent with the previously identified comorbidity‐independent association between BN and suicidality among adults .…”

Section: Discussionsupporting

confidence: 91%

“…However, given that nearly all psychiatric disorders are associated with elevated suicide risk when considered at a univariate level, it is important to disentangle whether EDs themselves, psychiatric comorbidities, or both account for lifetime suicide risk in EDs. By considering the ED–suicide link at a multivariate level, we may begin to better understand the symptoms (e.g., eating, mood, or anxiety) that drive suicide risk in EDs …”

Section: Introductionmentioning

confidence: 99%

“…This study used population‐based surveys to (1) assess the association between lifetime EDs (i.e., BED, BN, and AN) and suicide ideation, planning, and attempting, specifically investigating suicide risk in BED, and (2) examine the temporal association between the ages of onset of BED and suicide ideation, planning, and attempting. BED and BN share many symptoms, and given that previous research indicates that AN and BN are associated with elevated suicide risk beyond that accounted for by comorbid mood, anxiety, and substance use disorders, we predicted that lifetime BED would be associated with suicide risk when adjusting for comorbid disorders. Given that BN typically onsets before suicidality, we predicted that BED would onset before suicidality.…”

Section: Introductionmentioning

confidence: 99%

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Suicidality in adolescents and adults with binge‐eating disorder: Results from the national comorbidity survey replication and adolescent supplement

Forrest

Zuromski

Dodd

et al. 2016

Intl J Eating Disorders

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BED, comorbid disorders, and suicidality share common factors and interrelations, and individuals with BED and comorbid disorders may be at particularly high risk for suicidal outcomes. The presence of BED in adolescence may serve as a marker for more severe symptomatology that precedes the occurrence of suicidality. Research is needed to understand how eating disorder symptoms, comorbid symptoms, and suicidality affect one another over time. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2017; 50:40-49).

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Suicidality in adolescents and adults with binge‐eating disorder: Results from the national comorbidity survey replication and adolescent supplement

Forrest

Zuromski

Dodd

et al. 2016

Intl J Eating Disorders

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“…Controlling for these other types of psychopathology is necessary for future work to understand how ED symptoms uniquely contribute to experiencing suicidal ideation. However, previous work has found that the co‐occurrence of other mental health conditions (e.g., major depressive disorder, anxiety disorders, substance abuse disorders) did not fully explain the relationship between EDs and suicidality, suggesting that these shared mechanisms alone cannot account for the co‐occurrence of these conditions (Yao et al, ). Moreover, we only assessed suicidal ideation; future work should explore whether emotion regulation strategies mediate the relationship between disordered eating and other forms of suicidality.…”

Section: Limitations and Directions For Future Researchmentioning

confidence: 96%

Expressive suppression mediates the relation between disordered eating and suicidal ideation

et al. 2019

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Objective Although disordered eating is robustly associated with suicidal thoughts, it is not well understood why these conditions relate to each other. Emotion dysregulation is a shared risk factor for disordered eating and suicidal thoughts. Individuals with dysregulated emotions struggle to select appropriate strategies to modulate emotions and the strategies they use might explain some of the shared variances. Thus, we examined whether emotion regulation strategies mediated the relationship between disordered eating and suicidal ideation. Method Adult participants (N = 230) completed questionnaires on current disordered eating symptoms, emotion regulation strategies, and current suicidal ideation. Results Disordered eating symptoms positively associated with suicidal ideation. In addition, expressive suppression mediated the relation between disordered eating symptoms and current suicidal ideation. No relation was found for cognitive reappraisal. Conclusions The use of expressive suppression as an emotion regulation strategy may be related to increased suicidal ideation in individuals who express concerns about eating.

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“…AN is associated with high psychiatric comorbidity, high suicide risk, and has the highest mortality rate of any psychiatric disorder . With the advent of DSM‐5, 2 a presentation of ‘atypical AN’ has also been recognized in which an individual meets all of the diagnostic criteria for AN, except that despite significant weight loss, the individual's weight is within or above the normal range.…”

Section: What Is Anorexia Nervosa?mentioning

confidence: 99%

Reconceptualizing anorexia nervosa

Bulik

Flatt

Abbaspour

et al. 2019

Psychiatry Clin Neurosci

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Anorexia nervosa (AN) has one of the highest mortality rates of any psychiatric disorder. Treatments are often ineffective and relapse is common. Most research attempting to understand the underlying causes and maintenance factors of AN has focused on environmental contributions, yet there is much to be explored in terms of biological risk and maintenance factors. In this paper, we focus primarily on AN research related to genetics and the complex microbial community in the gut (intestinal microbiota), and how these impact our conceptualization of this disorder. Emerging research identifying significant negative genetic correlations between AN and obesity suggests that the conditions may represent ‘metabolic bookends’. The identification of underlying biological mechanisms may provide both insight into extreme weight dysregulation on both ends of the spectrum and new possible points of entry for AN treatment. Additionally, the reported microbial imbalance (dysbiosis) in the gut microbiota in AN patients, potentially due to a nutrient‐ and energy‐deprived gut environment, implies alterations in functional and metabolic capacity of the gut microbiome. The extent to which AN and obesity can also be considered to be ‘microbiome bookends’ requires further investigation. Finally, we discuss ongoing and future AN projects exploring the interplay between host genomics, the environment, and cumulative microbial genomes (microbiome) as well as interventions at the microbial and gut level.

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Familial Liability for Eating Disorders and Suicide Attempts

Cited by 85 publications

References 33 publications

Suicidality in adolescents and adults with binge‐eating disorder: Results from the national comorbidity survey replication and adolescent supplement

Suicidality in adolescents and adults with binge‐eating disorder: Results from the national comorbidity survey replication and adolescent supplement

Expressive suppression mediates the relation between disordered eating and suicidal ideation

Reconceptualizing anorexia nervosa

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