Familial Incidence of Ruptured Intracranial Aneurysms

Acosta-Rua, Gaston J.

doi:10.1001/archneur.1978.00500340051010

Cited by 35 publications

(6 citation statements)

References 14 publications

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“…[3][4][5][6][7][8] One study investigated the association of single nucleotide polymorphisms on 9p21 with IA location and found that posterior communicating artery and posterior circulation IAs had stronger associations than the anterior circulation group. 11 Recent genomewide association studies have identified loci associated with IA, 12-14 but these studies did not stratify by IA location, and this is an unexplored avenue of investigation.…”

Section: Discussionmentioning

confidence: 99%

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Familial Intracranial Aneurysms

Mackey

Brown

Moomaw

et al. 2013

Stroke

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The Familial Intracranial Aneurysm (FIA) Study is a multicenter international study with 41 recruitment sites in North America, Australia, and New Zealand. The detailed methodology of the FIA Study has been published previously. 9 The overall goal of the study is to identify genetic and other risk factors for the formation and rupture of IAs. The FIA study was approved by the Institutional Review Boards/Ethics Committees of all recruitment and analytic sites.Background and Purpose-Previous studies have suggested that family members with intracranial aneurysms (IAs) often harbor IAs in similar anatomic locations. IA location is important because of its association with rupture. We tested the hypothesis that anatomic susceptibility to IA location exists using a family-based IA study. Methods-We identified all affected probands and first-degree relatives (FDRs) with a definite or probable phenotype in each family. We stratified each IA of the probands by major arterial territory and calculated each family's proband-FDR territory concordance and overall contribution to the concordance analysis. We then matched each family unit to an unrelated family unit selected randomly with replacement and performed 1001 simulations. The median concordance proportions, odds ratios (ORs), and P values from the 1001 logistic regression analyses were used to represent the final results of the analysis.

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Section: Discussionmentioning

confidence: 99%

“…1,2 Previous reports noted family members with IAs in similar locations and twins with IAs in identical locations. [3][4][5][6][7][8] These data suggest that there may be heritable susceptibility to IA location. We tested the hypothesis that anatomic susceptibility to IA location exists using a large multicenter family-based IA study.…”

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confidence: 83%

Familial Intracranial Aneurysms

Mackey

Brown

Moomaw

et al. 2013

Stroke

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“…Previous studies have shown cases of identical aneurysm location in members of the same family or in twins. 1,3,17,25,27 Indeed, the Familial Intracranial Aneurysm (FIA) study reported a high agreement of aneurysm location among IA patients belonging to the same family. 26 These observations may thus suggest that anatomical vulnerability to aneurysm formation is hereditary.…”

Section: Discussionmentioning

confidence: 99%

Is there an inherited anatomical conformation favoring aneurysmal formation of the anterior communicating artery?

Bourcier

Lenoble

Guyomarc’h-Delasalle

et al. 2017

Journal of Neurosurgery

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OBJECTIVE The pathophysiological mechanisms responsible for the formation of intracranial aneurysms (IAs) remain only partially elucidated. However, current evidence suggests a genetic component. The purpose of this study was to investigate the specific anatomical variations in the arterial complex that are associated with the presence of anterior communicating artery (ACoA) aneurysms in the familial forms of IAs. METHODS This multicenter study investigated bifurcation IAs in patients who had a sporadic ACoA IA without a family history of IA (SACAA group), in patients who had an ACoA IA with a family history of IA (FACAA group), and in their healthy first-degree relatives (HFDRs). Through the use of MR angiography (MRA) reconstructions, the symmetry of the A segments and the angle between the A and A segments were analyzed on 3D models for each group. These measurements were then compared among the 3 groups. RESULTS Twenty-four patients with SACAA, 24 patients with FACAA, and 20 HFDRs were included in the study. Asymmetrical configuration of the A segments was more frequent in the FACAA group than in the HFDR group (p = 0.002). The aneurysm-side A-A angle was lower in the FACAA group (p = 0.003) and SACAA group (p = 0.007) than in the HFDR group. On the contralateral side, there was no difference in A-A angles between groups. CONCLUSIONS The anatomical shape of the ACoA complex seems to be similarly associated with the presence of ACoA IAs in both the FACAA and SACAA groups. This highlights the role played by hemodynamic constraints in aneurysm formation and questions the hypothesis of the hereditary character of these anatomical shapes.

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“…Plusieurs auteurs présentent l'étude d'une seule famille en y exposant les cas (Ullrich et Sugar 1960;Graf 1966;Beumont 1968;Kak 1970;Brisman et Abbassioun 1971;Edelsohn et al 1972;Nagae et al 1972;Hashimoto 1977;Acosta-Rua 1978;Fox et Ko 1980;Fox 1982;Halal et al 1983;Berg et al 1987). Toutes ces études nous amènent à nous interroger de plus en plus sur les facteurs qui prédisposent ces individus à développer un anévrisme.…”

Section: éPidémiologie Génétiqueunclassified

Epidemiologie genetique des anevrismes intracraniens familiaux au Saguenay-Lac-St-Jean

Gauthier¹

1992

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Familial Incidence of Ruptured Intracranial Aneurysms

Cited by 35 publications

References 14 publications

Familial Intracranial Aneurysms

Familial Intracranial Aneurysms

Is there an inherited anatomical conformation favoring aneurysmal formation of the anterior communicating artery?

Epidemiologie genetique des anevrismes intracraniens familiaux au Saguenay-Lac-St-Jean

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