Familial Hypercholesterolemia With Coexisting Renovascular Stenosis and Premature Coronary Artery Disease

Mehta, Ojas; Cameron, James D.; Mirzaee, S.

doi:10.1093/ajh/hpz037

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…However, even if patients with a second dyslipidemia disease (such as nephrotic syndrome and renal insufficiency ( 20 , 21 ) were excluded, the screening rates of FH patients were still higher in the Department of Nephrology. These data may be supported by a certain number of patients with renal arteriosclerosis ( 22 ). As a result, it is necessary for nephrologists to focus on finding FH patients.…”

Section: Discussionmentioning

confidence: 63%

Screening and clinical characteristics analysis of familial hypercholesterolemia in a tertiary public hospital

Shen

Luo

et al. 2023

Front. Cardiovasc. Med.

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Background and aimsFamilial hypercholesterolemia (FH) is becoming a global burden. However, it remains underdiagnosed and undertreated worldwide. This study aimed to observe the screening rate of FH patients and department distribution among hospitalized patients using different diagnostic criteria.MethodsA total of 45,410 inpatients with LDL-C ≥3.5 mmol/L between 2008 and 2019 were included from The Second Affiliated Hospital of Nanchang University. Inpatients are diagnosed and divided into groups by Dutch Lipid Clinic Network (DLCN) criteria, Chinese-modified DLCN criteria and Chinese expert consensus (CEC) criteria.ResultsThere were 172, 1,076 and 115 inpatients included in the DLCN group, Chinese-modified DLCN group and CEC group, respectively (screening rates: 0.38%, 2.37% and 0.25%). These FH patients had a very high risk of atherosclerotic cardiovascular disease (ASCVD) (55.7%–74.4%), especially in the DLCN group and CEC group (70.4%–74.4%). More than half of the patients were in the Department of Cardiology, and other high-risk departments included Neurology, Nephrology, Vascular Surgery, Otolaryngology & Head Neck Surgery and Traditional Chinese Medicine (24.35%–31.51%). Overall, hypertension, coronary heart disease, carotid arteriosclerosis, hepatic cyst, arrhythmia, and nonalcoholic fatty liver disease were common accompanying diseases with FH.ConclusionsIt is necessary to establish appropriate diagnostic criteria and more positive treatment strategies for the FH inpatient population. In addition, promoting awareness of FH among doctors from other departments is also necessary. Therefore, developing a comprehensive management strategy for FH disease is very important.

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Section: Discussionmentioning

confidence: 63%

Screening and clinical characteristics analysis of familial hypercholesterolemia in a tertiary public hospital

Shen

Luo

et al. 2023

Front. Cardiovasc. Med.

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Emergent players in renovascular disease

et al. 2022

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Renovascular disease (RVD) remains a common etiology of secondary hypertension. Recent clinical trials revealed unsatisfactory therapeutic outcomes of renal revascularization, leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury, cellular senescence, and microvascular remodeling. This interplay resulted in a shift of our understanding of RVD from a mere hemodynamic disorder to a pro-inflammatory and pro-fibrotic pathology strongly influenced by systemic diseases like metabolic syndrome (MetS), hypertension, diabetes mellitus, and hyperlipidemia. Novel diagnostic approaches have been tested for early detection and follow-up of RVD progression, using new imaging techniques and biochemical markers of renal injury and dysfunction. Therapies targeting some of the pathological pathways governing the development of RVD have shown promising results in animal models, and a few have moved from bench to clinical research. This review summarizes evolving understanding in chronic ischemic kidney injury.

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Familial Hypercholesterolemia With Coexisting Renovascular Stenosis and Premature Coronary Artery Disease

Cited by 2 publications

References 18 publications

Screening and clinical characteristics analysis of familial hypercholesterolemia in a tertiary public hospital

Screening and clinical characteristics analysis of familial hypercholesterolemia in a tertiary public hospital

Emergent players in renovascular disease

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