Familial history of hypertension as a predictor of increased arterial stiffness in normotensive offspring

Abstract

BackgroundIncreased arterial stiffness can be used as a prognostic marker of arterial hypertension. The relationship between arterial stiffness and arterial hypertension seems to be reciprocal.ObjectiveEvaluation of changes of the arterial elastic prosperities in normotensive subjects, with and without parental history of hypertension.Subjects and MethodsOne hundred and ten normotensive individuals, aged 20–30 years, were divided into two groups: group-A (n = 57) and group-B (n = 53) subjects with positive and negative parental history of hypertension, respectively. Systolic, diastolic and pulse pressures were measured using mercury sphygmomanometer. The elastic properties of the ascending aorta and the common carotid arteries were assessed using M-mode echo and B-mode imaging, respectively. Stiffness index of the digital volume pulse (SIDVP) was measured in the right index finger using photoplethysmography.ResultsGroup A subjects showed higher aortic stiffness index (p = 0.002), carotid stiffness index (p = 0.001), carotid pulse wave velocity (p ⩽ 0.001) and stiffness index of digital volume pulse (p = 0.001). Group A subjects showed lower aortic distensibility (p = 0.001), aortic strain (p = 0.004), changes in aortic diameter (p = 0.022), carotid distension (p = 0.026), carotid distensibility coefficient (p ⩽ 0.001) and carotid compliance coefficient (p = 0.002).ConclusionThe aortic and carotid stiffness parameters and SIDVP were higher in normotensive offspring of hypertensive parents. This finding could direct the attention towards the increased cardiovascular risk in this group and thus prompt earlier and tighter prevention of cardiovascular risk factors.

Association of Endothelial Function with Parental Hypertension in Normotensive-Obese African-American Women: A Pilot Study

“…We confirmed the apparent physiological relationship between body stature and AI by virtue of our finding that body height and the baseline pre-exercise AI were negatively correlated. Our finding that parental history of hypertension was not predictive of increased arterial stiffness is not consistent with a report that parental hypertension was associated with increased aortic stiffness [40]. This inconsistency is likely explained by the facts that, in the aforementioned study the body weight, body mass index, systolic and pulse pressures were significantly greater in the group with parental histories of hypertension than in the group without such histories, whereas, these parameters were not different, well-matched between our study groups.…”

Prevalence and factors associated with type 2 diabetes mellitus and hypertension among the hill tribe elderly populations in northern Thailand

“…The study of Ghada et al [49] in Egypt showed a strong association between a family history of HT and the development of HT in one’s offspring. A family history has been detected as a risk factor for HT among young adults and the elderly population in several countries [50–52].…”

Factores de Riesgo asociados a la Hipertensión Arterial en adultos

“…En un estudio realizado en el Cairo, fueron escogidos 110 individuos y divididos en dos grupos, el primero con antecedentes familiares de hipertensión positivos y el segundo grupo sin antecedentes familiares de hipertensión, con el fin de estudiar la relación del aumento de la rigidez aortica ya que esta es un determinante importante de futuros aumentos en la presión arterial (PA) y la progresión de la hipertensión, con la historia familiar de los pacientes de HTA, los resultados demostraron que había un mayor aumento de la rigidez aortica en personas normotensas con antecedentes familiares de Hipertensión que aquellas que no tenían antecedentes familiares con hipertensión. [16] Datos similares fueron encontrados en otros estudios con relación a los individuos con antecedentes familiares de HTA [17], [18], [19].…”