“Familial” Generalized Argyria

Bianchi, Luca

doi:10.1001/archderm.142.6.789

Cited by 9 publications

(8 citation statements)

References 5 publications

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“…[52] Acitretin has been reported to cause improvement in individual case reports in patients of porokeratosis with graft versus host disease, generalized linear porokeratosis, erosive pustular dermatosis of scalp, and lichen amyloidosis. [53][54][55] Prophylactic use (chemoprevention) or treatment of precancerous and malignant conditions There are case reports of acitretin used for prevention of cutaneous malignancies in solar-damaged skin and in genetic syndromes predisposing to skin cancer, for example, epidermodysplasia verruciformis, [56] graft versus host disease, [57] xeroderma pigmentosa, [58] keratoacanthoma, [59] basal cell naevus syndrome (etretinate). In epidermodysplasia verruciformis acitretin has been used as an adjunct in combination with interferon alfa-2a but as monotherapy was ineffective.…”

Section: Infectionsmentioning

confidence: 99%

Acitretin in dermatology

Sarkar¹,

Chugh²,

Garg³

2013

Indian J Dermatol Venereol Leprol

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Acitretin, a synthetic retinoid has gradually replaced etretinate in today's dermatologic practice because of its more favorable pharmacokinetics. Acitretin over the past 20 years has proven useful in a number of difficult-to-treat hyperkeratotic and inflammatory dermatoses and nonmelanoma skin cancers. It is effective both as monotherapy and in combination with other drugs for hyperkeratotic disorders. It is considered to be an established second line treatment for psoriasis and exerts its effect mainly due to its antikeratinizing, antiinflammatory, and antiproliferative effect. Its antineoplastic properties make it a useful agent for cancer prophylaxis. Evidence-based efficacy, side-effect profile, and approach to the use of acitretin would be discussed in this review. In addition to its approved uses, the various off label uses will also be highlighted in this section. Since its use is limited by its teratogenic potential and other adverse effects, including mucocutaneous effects and hepatotoxicity, this review would summarize the contraindications and precautions to be exercised before prescribing acitretin.

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Section: Infectionsmentioning

confidence: 99%

Acitretin in dermatology

Sarkar¹,

Chugh²,

Garg³

2013

Indian J Dermatol Venereol Leprol

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“…Generalized argyria symptoms include pigmentation on the skin, eyes, face, 'V of the neck´, waist, bald scalp, hands, nails and forearms (Legat et al 1998, Bouts 1999, Johnston et al 1999, Graham et al 2004, Brandt et al 2005, Bianchi et al 2006. Their light microscopical studies have revealed that fine granules cluster in the periadnexal basement membrane and dermal elastic fibres (White et al 2003).…”

Section: Argyria and Argyrosismentioning

confidence: 99%

Silver or silver nanoparticles: a hazardous threat to the environment and human health?

Panyala¹,

Peña‐Méndez²,

Havel³

2008

JAB

464

250

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Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles that measure in nanometers. These nanomaterials are already having an impact on health care. Now-a-days we are using nanoproducts in various fields. Of these, silver nanoparticles are playing a major role in the field of nanotechnology and nanomedicine.Their unique size-dependent properties make these materials superior and indispensable as they show unusual physical, chemical and biological properties. Silver nanoparticles have potential antimicrobial activity towards many pathogenic microbes. Along with this antimicrobial activity, silver nanoparticles are showing unacceptable toxic effects on human health and the environment. The chronic exposure to silver causes adverse effects such as permanent bluish-grey discoloration of the skin (argyria) and eyes (argyrosis). Besides argyria and argyrosis, exposure to soluble silver compounds may produce other toxic effects like liver and kidney damage, irritation of the eyes, skin, respiratory and intestinal tract and changes to blood cells. This review summarizes the hazardous effects of silver nanoparticles in the environment and theirs toxic effects on human health.

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“…[5,6, It is worth mentioning herein, two reports of familial argyria in members of the same family due to prolonged use of silver containing formulations as a form of alternative medicine. [53,54] Apart from this, localized cases of argyria have also been reported following acupuncture. [55][56][57] Personal and socio-cultural Cases of argyria have been associated with certain personal and socio-cultural practices.…”

Section: Discussion Discussionmentioning

confidence: 98%

Use of fine needle aspirate from peripheral nerves of pure-neural leprosy for cytology and PCR to confirm the diagnosis: A pilot study

Reja¹,

De²,

Biswas³

et al. 2013

Indian J Dermatol Venereol Leprol

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Our study demonstrates that in the field of laboratory diagnosis of PNL cases, FNAC in combination with ZN staining for acid-fast bacilli (AFB) and Multiplex-PCR can provide a rapid and definitive diagnosis for the majority of PNL cases. FNAC is a less-invasive, outdoor-based and simpler technique than invasive nerve biopsy procedure. Thus, this study may enlighten the future path for easy and reliable diagnosis of PNL.

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“Familial” Generalized Argyria

Cited by 9 publications

References 5 publications

Acitretin in dermatology

Acitretin in dermatology

Silver or silver nanoparticles: a hazardous threat to the environment and human health?

Use of fine needle aspirate from peripheral nerves of pure-neural leprosy for cytology and PCR to confirm the diagnosis: A pilot study

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