Familial cutaneous leiomyomatosis in multiple generations with varied morphological presentations

Abstract

amenable to local anaesthesia, 1 we applied standard surgical excision (SSE) under general anaesthesia for all our patients as the average size of lesion in our study is 7.2 cm. Resecting of such a giant tumours with MMS may take entire day or longer, 1 so SSE under general anaesthesia is better option and it does not mean that this kind of tumours cannot be operated under local anaesthesia.

An Aggressive Clinical Presentation of Familial Leiomyomatosis Associated with a Fumarate Hydratase Gene Variant of Uncertain Clinical Significance

“…They can be divided in subgroups by their clinical and histological aspects: piloleiomyomas, genital leiomyomas and angioleiomyomas. Mosaic presentation may be found as well as a different degree of gene penetrance as found in the family reported here ( 3 ).…”