“…Familial cortical myoclonic tremor with epilepsy (FCMTE), also known as familial adult myoclonic epilepsy (FAME), autosomal dominant cortical myoclonus and epilepsy (ADCME), and benign adult familial myoclonic epilepsy (BAFME), is characterized by myoclonus affecting the limbs distally and generalized tonic-clonic seizures, with onset in the second or third decade. 58 Additional features may include mild cerebellar signs and cognitive decline. 58 The inheritance pattern is autosomal dominant and, recently, inserted pentamer repeats, presumed to lead to RNA toxicity, have been identified in STARD7, SAMD12, TNRC6A and RAPGEF2, [59][60][61] in keeping with previously implicated loci.…”