Familial Colorectal Cancer and Genetic Susceptibility: Colorectal Risk Variants in First-Degree Relatives of Patients With Colorectal Cancer

Gargallo-Puyuelo, C J; Lanas, Ángel; Carrera‐Lasfuentes, Patricia; Ferrández, Ángel; Quintero, Enrique; Carrillo, Marta; Alonso‐Abreu, Inmaculada; García-González, María Asunción

doi:10.14309/ctg.0000000000000301

Cited by 4 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We hypothesized that these two lncRNAs are BMI-associated lncRNAs in lung. SNPs in LINC01500 have been reported to link with childhood obesity and familial colorectal cancer (34,35). In the meantime, little is known for lnc-MAFB-1, which was once known as AL035665.1 and RP4-644L1.2 in previous human assembly annotations with ensemble id ENSG00000229771.…”

Section: Identification Of Bmi-associated Lncrnas In Lungmentioning

confidence: 99%

Characterization of Obesity-associated Long Noncoding RNAs in Lung

Fu¹,

Huang

Lin³

et al. 2023

Preprint

View full text Add to dashboard Cite

Obesity often increases the risk of cancer and worsens the prognosis. Unlike most types of cancer, several studies concluded that obesity had an inverse influence on LUAD survival. Increasing evidence showed that obesity-related and adipocyte-derived lncRNAs were associated with cancer initiation, progression, drug resistance, and the tumor microenvironment in lung cancer. In the present study, we identified two BMI-associated lncRNAs (LINC01500 and lnc-MAFB-1) that could potentially regulate tumor progression in LUAD. Both lncRNAs downregulated significantly in the obese lung. The increased expression level of LINC01500 could be observed in LUAD tumors and predict poorer survival. In addition, through estimation from bulk RNA-seq and profiling in single-cell sequencing, we found that the expressions of both BMI-associated lncRNAs were associated with macrophages. The downregulation of BMI-associated lncRNAs could create a less immunosuppressive microenvironment, leading to a more efficient response toward immunotherapy. To our knowledge, this is the first study to investigate BMI-associated lncRNAs in lung. We believe our findings can expand the understanding of obesity and the immune microenvironment in lung cancer.

show abstract

Section: Identification Of Bmi-associated Lncrnas In Lungmentioning

confidence: 99%

Characterization of Obesity-associated Long Noncoding RNAs in Lung

Fu¹,

Huang

Lin³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Individuals with a family history of colon cancer or adenomatous polyp are subject to higher risks of colon cancer [ 12 – 15 ]. The presence of colon cancer in first-degree relatives increases the incidence rate of colorectal cancer to 1.7 times as much as that of the normal population [ 16 ]. A higher incidence rate has also been observed for colorectal cancer among the first-degree relatives of patients with adenomatous polyps [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

The frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among PERSIAN Guilan Cohort Study population (PGCS)

Matin,

Joukar,

Maroufizadeh

et al. 2024

BMC Gastroenterol

View full text Add to dashboard Cite

Background This study aimed to investigate the frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among the Prospective Epidemiological Research Studies in Iran (PERSIAN )Guilan Cohort Study (PGCS) population. Methods In this cross-sectional study, 162 first-degree relatives with a history of colorectal lesions were randomly selected from 52 participants in PGCS. All subjects underwent total colonoscopy by a gastroenterologist, and a pathologist evaluated colorectal biopsies. Also, individuals’ demographic information, clinical data, and dietary habits were recorded. Results The mean age of the participants was 56.55 ± 7.04. Of 86 colon polyps, 52 neoplastic and 34 non-neoplastic polyps were observed in 56 patients (34.6%). Individuals with age > 60 years had 3.29-fold increased odds of developing colorectal polyps (OR = 3.29, 95% CI: 1.13–9.56, P = 0.029). The smokers were 2.73 times more susceptible to developing colorectal polyps than non-smokers (OR = 2.73, 95% CI: 1.24–6.02, P = 0.013). Moreover, consumption of vegetables more than three times per day was associated with decreased OR of colorectal polyp development (OR = 0.43, CI: 0.19–0.98, P = 0.045). Conclusions Considering the high prevalence of neoplastic colorectal polyps among the first-degree relatives of patients with colorectal lesions, early screening is recommended for individuals with a family history of colorectal lesions.

show abstract

“…People with family history of colon cancer or adenomatous polyp are subject to higher risks of colon cancer [7][8][9][10]. The presence of colon cancer in rst-degree relatives increases the incidence rate of colorectal cancer to 1.7 times as much as that of the normal population [11]. Higher incidence rate has also been observed for colorectal cancer among the rst-degree relatives of the patients with adenomatous polyp [12].…”

Section: Introductionmentioning

confidence: 99%

The frequency of colon lesions in the first-degree relatives of patients with adenomatous polyp or premalignant/ malignant colon lesions referring to the PERSIAN Guilan Elderly Cohort Study (PGECS)

Matin

Joukar

Maroufizadeh

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Family history of colon cancer or adenomatous polyp is associated with an increased risk of colon cancer. The aim of this study was to investigate the frequency of colonic lesions in the first-degree relatives of patients with adenomatous polyp or premalignant/ malignant colon lesions referring to the geriatric cohort of Guilan. Methods In this cross-sectional study, 162 subjects who were the first-degree relatives of 52 patients with adenomatous polyp were investigated and underwent total colonoscopy based on the guidelines proposed for screening colorectal cancer. Moreover, the subjects’ demographic information, colonoscopy results, and pathological findings were recorded using a checklist Logistic regression with backward elimination (p-value for removal > 0.1) was used to identify factors associated with presence of colon polyps. Odds ratio (OR) and 95% confidence interval (CI) were calculated. Results In total, 86 colon polyps (52 neoplastic and 34 non-neoplastic polyps) were observed in 56 (34.6%) individuals. Being older, higher BMI, cigarette smoking, and diabetes were significantly associated with a greater risk of having colon polyps. In contrast, higher consumption of vegetables as well as fruits were significantly associated with a less risk of having colon polyps. Conclusions Considering the high prevalence of neoplastic colon polyps among the first-degree relatives of the patients with adenomatous polyp, early screening is recommended for the people with family history of this disease in the same way that people with family history of colorectal cancer (CRC) are screened.

show abstract

Familial Colorectal Cancer and Genetic Susceptibility: Colorectal Risk Variants in First-Degree Relatives of Patients With Colorectal Cancer

Cited by 4 publications

References 30 publications

Characterization of Obesity-associated Long Noncoding RNAs in Lung

Characterization of Obesity-associated Long Noncoding RNAs in Lung

The frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among PERSIAN Guilan Cohort Study population (PGCS)

The frequency of colon lesions in the first-degree relatives of patients with adenomatous polyp or premalignant/ malignant colon lesions referring to the PERSIAN Guilan Elderly Cohort Study (PGECS)

Contact Info

Product

Resources

About