Familial Clustering of Habitual Constipation: A Prospective Study in Children From West Virginia

Ostwani, Waseem; Dolan, Jenna; Elitsur, Yoram

doi:10.1097/mpg.0b013e3181a0a595

Cited by 27 publications

(20 citation statements)

References 16 publications

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“…The present study supports findings from previous studies that a positive family history of constipation and low consumption of dietary fiber are significantly associated with constipation in children . Interestingly, it was noted in the present study that toilet training was found to be significantly associated with a higher constipation rate.…”

Section: Discussionsupporting

confidence: 92%

Use of Rome II versus Rome III criteria for diagnosis of functional constipation in young children

Osatakul

Puetpaiboon

2014

Pediatrics International

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Section: Discussionsupporting

confidence: 92%

Use of Rome II versus Rome III criteria for diagnosis of functional constipation in young children

Osatakul

Puetpaiboon

2014

Pediatrics International

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“…This may highlight the possibility that differing intrafamilial environment may be significant in those with CC who seek referral based care and those that do not. These differing environments may explain our negative findings from a population-based perspective but the apparently positive findings from referral based settings [15–17]. …”

Section: Discussionmentioning

confidence: 99%

“…A recent observation from Asia reported familial aggregation of constipation in adult patients evaluated at a single tertiary center and suggested that those with constipation and a positive family history of CC may be clinically different than constipated patients without a family history [15,16]. Familial aggregation of CC was also reported to occur in pediatric patients in a tertiary care setting [17]. Whether familial aggregation truly occurs in CC in the community remains to be documented, and if clustering occurs whether this is explained by genetic factors, environmental factors, or an interplay of both is currently unknown.…”

Section: Introductionmentioning

confidence: 99%

Lack of Familial Aggregation in Chronic Constipation Excluding Irritable Bowel Syndrome: A Population-Based Study

Chang¹,

Locke

Schleck

et al. 2014

Dig Dis Sci

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Background Despite strong evidence supporting a genetic and gene-environment interaction in the irritable bowel syndrome (IBS), the role of genes and early life in another common functional bowel disorder, chronic constipation (CC) has been little studied. Aim To determine if familial aggregation occurs in CC, and whether risk factors differed in those with family members. Methods A randomly selected population-based cohort from Olmsted County, MN, was surveyed (n=8006); 3831 completed questionnaires (response rate 48%). Cases were identified based upon their responses to a validated questionnaire and meeting Rome criteria for CC. Controls were matched one-to-one by age and gender. IBS (by Rome II criteria) was excluded. Recruitment of case and control probands occurred in 2010–2011 by mailing a family information form; then first degree relatives (FDR) were mailed a questionnaire. All potential proband participants were not informed of CC status. Results Overall 1185 cases who met criteria for CC without symptoms of IBS and 1185 controls were surveyed; 309 case and 336 control probands provided data. The proportion of family members having CC was not associated with case status, and the constipation status of FDR was not significantly associated with case-controls status of the respective probands. Symptom burden in FDR was associated with gender and SSC score, but not age or proband status. Conclusions No evidence of familial aggregation was observed in adults from the community with CC (excluding IBS). Our data suggest environmental factors in later life more likely account for adult CC.

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“…Since FC seems to occur more often in certain families, genetic factors may contribute to the etiology of childhood constipation [ 22 ]. However, studies have failed to identify mutations in specifi c genes associated with FC [ 23 ].…”

Section: Geneticsmentioning

confidence: 99%

Functional Constipation in Children

Koppen

Benninga

2016

Pediatric Neurogastroenterology

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Constipation is a common and bothersome problem in children. It may present with infrequent bowel movements with fecal incontinence, hard stools, large stools, painful defecation, and abdominal pain [ 1 ]. In approximately 95 % of children with constipation, no organic cause can be identifi ed, these children suffer from functional constipation (FC) [ 2 ]. The prevalence of FC ranges between 0.7 and 29.6 % and it occurs more often in girls than in boys (ratio: 2.1:1) [ 3 ]. The diagnosis of FC is based on the pediatric diagnostic Rome criteria for functional gastrointestinal disorders (Table 42.1 ) [ 4 ]. These criteria were revised in the spring of 2016 [ 5 , 6 ] (for more information, see Benninga et al.: http:// www.ncbi.nlm.nih.gov/pubmed/27144631 or Hyams et al.: http://www.ncbi.nlm.nih.gov/pubmed/27144632 . Physiology Meconium Passage and Defecation FrequencyIn more than 99 % of healthy term neonates, the fi rst meconium passes within the fi rst 48 h of life [ 5 , 6 ]. Delayed passage of the fi rst meconium beyond the fi rst 48 h of life is suggestive for an organic defecation disorder (e.g., Hirschsprung's disease). During the fi rst months of life, the defecation frequency may vary from child to child, this is partially dependent on feeding type; breastfed children have a higher defecation frequency than formula-fed infants [ 6 ].In the fi rst weeks of life, the defecation frequency lies around 4 stools a day, this frequency gradually decreases over time until it is approximately once a day in children at the age of 4 years [ 6 , 7 ]. In older children, defecation usually occurs either daily or every other day [ 8 ]. Defecation DynamicsThe physiological dynamics of defecation are complex and rely on several intricate processes involving the autonomic and somatic nervous system, the pelvic fl oor muscles, and the internal and external anal sphincters. In the colon, feces is propelled by propagating colonic contractions. Several different colonic motor patterns have been described [ 9 , 10 ], but the most well-recognized propagating motor patterns are high-amplitude propagating contractions (HAPCs ). These motor patterns are associated with the mass movement of colonic content and spontaneous defecation in healthy adults [ 11 , 12 ]. Anterograde propagation of feces through the colon leads to fi lling of the rectum, which induces a relaxation of the internal anal sphincter, allowing feces to travel further down the anal canal; this refl ex is known as the recto-anal inhibitory refl ex (RAIR ). Subsequently, sensory stimuli caused by rectal distension and by the contact between fecal material and the mucosa of the proximal part of the anal canal result in an urge to defecate. At this point, voluntary contraction of the external anal sphincter can postpone defecation, by moving the fecal load back, higher up in the anal canal and rectum, until the place and time are appropriate for defection. When defecation is initiated, voluntary relaxation of the external anal sphincter and the pelvic fl oor musculature (...

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Familial Clustering of Habitual Constipation: A Prospective Study in Children From West Virginia

Abstract: Habitual constipation in children seemed to cluster in families. The pathophysiology behind this phenomenon is yet unknown.

Cited by 27 publications

References 16 publications

Use of Rome II versus Rome III criteria for diagnosis of functional constipation in young children

Use of Rome II versus Rome III criteria for diagnosis of functional constipation in young children

Lack of Familial Aggregation in Chronic Constipation Excluding Irritable Bowel Syndrome: A Population-Based Study

Functional Constipation in Children

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