Familial Clustering of ESRD in the Norwegian Population

Skrunes, Rannveig; Svarstad, Einar; Reisæter, Anna Varberg; Vikse, Bjørn Egil

doi:10.2215/cjn.01680214

Cited by 83 publications

(64 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alternatively, in the general population, we know that the blood relatives of patients with ESRD have an increased risk of developing ESRD. 7 Additional studies that provide longer follow-up for unrelated donors will be needed to understand this issue better.…”

Section: Discussionmentioning

confidence: 99%

Renal Function Profile in White Kidney Donors: The First 4 Decades

Ibrahim¹,

Foley²,

Reule³

et al. 2016

JASN

110

116

View full text Add to dashboard Cite

Previous studies reported the risk of ESRD after kidney donation, but not the renal outcomes that precede ESRD. Here, we estimated the risk of proteinuria, reduced GFR, and ESRD in 3956 white kidney donors, assessed the contribution of postdonation hypertension and diabetes to these outcomes, and developed a risk calculator. After a mean6SD follow-up of 16.6611.9 years, 215 (6.1%) donors developed proteinuria. Men had a higher risk of proteinuria (hazard ratio [HR], 1.56; 95% confidence interval [95% CI], 1.18 to 2.05; P,0.001) as did those with higher body mass index (HR, 1.10; 95% CI, 1.06 to 1.13; P,0.001). ESRD associated with older age (HR, 1.07; 95% CI, 1.05 to 1.09; P,0.001), higher body mass index (HR, 1.08; 95% CI, 1.04 to 1.13; P,0.001), and higher systolic BP (HR, 1.02; 95% CI, 1.00 to 1.04; P=0.01) at donation. Postdonation diabetes and hypertension associated with a fourfold higher risk of proteinuria and a .2-fold higher risk of ESRD. Models predicting proteinuria and reduced eGFR performed well (C-index 0.77-1.00). In conclusion, severe reduction in GFR and ESRD after kidney donation were uncommon and were highly associated with postdonation diabetes and hypertension. Furthermore, information available before donation may predict long-term renal outcomes in white living kidney donors.

show abstract

Section: Discussionmentioning

confidence: 99%

Renal Function Profile in White Kidney Donors: The First 4 Decades

Ibrahim¹,

Foley²,

Reule³

et al. 2016

JASN

110

116

View full text Add to dashboard Cite

show abstract

“…Freedman et al [17] studied incident dialysis patients and found a 20% prevalence in a relative with ESKD. More recently, Skrunes et al [18 ]demonstrated that in a Norwegian ESKD population having a 1st-degree relative with ESKD conferred a 7-fold increase in the risk of developing kidney disease. However, few studies have examined both CKD and ESKD populations.…”

Section: Discussionmentioning

confidence: 99%

The Irish Kidney Gene Project - Prevalence of Family History in Patients with Kidney Disease in Ireland

Connaughton

Bukhari

Cassidy

et al. 2015

Nephron

View full text Add to dashboard Cite

Background: The prevalence of kidney disease (KD) due to inherited genetic conditions in Ireland is unknown. The aim of this study was to characterise an adult kidney disease population in Ireland and to identify familial clusters of kidney disease within the population. Methods: This was a multicenter cross-sectional study of patients with kidney disease in the Republic of Ireland, from January 2014 to September 2014, recruiting from dialysis units and out-patient renal departments. A survey was performed by collecting data on etiology of kidney disease and whether a family history of kidney disease exists. Medical records were cross-referenced to confirm the etiology of kidney disease. Results: A total of 1,840 patients were recruited with a mean age of 55.9 years (range 17-94.5) and a male predominance (n = 1,095; 59.5%). A positive family history was reported by 629 participants (34.2%). Excluding polycystic kidney disease (n = 134, 7.3%), a positive family history was reported by 495 participants (26.9%). Kidney disease due to an unknown etiology was the commonest etiology in the non-polycystic kidney disease group with a positive family history (10.6%, n = 67). Kidney diseases that are not classically associated with familial inheritance including tubulo-interstitial kidney disease, congenital abnormalities of the kidney and urinary tract and glomerulonephritis demonstrated familial clustering. Conclusion: In an Irish non-polycystic kidney disease population, 26.9% reports a positive family history. The commonest etiology of kidney disease in the positive family history cohort, excluding autosomal dominant polycystic kidney disease, was kidney disease due to unknown etiology. Examining families with kidney disease provides an opportunity to better understand disease pathogenesis and potentially identify genetic predispositions to kidney disease.

show abstract

“…It is well known that there is a familial clustering of ESRD [24,25]. Skrunes et al found increased mortality in first-degree relatives of patients with ESRD [26]. Differentiating potential effects of donation from hereditary factors is a problem in donor studies, since most donors are closely related with the recipient, and most studies do not include enough unrelated donors to perform separate analyses in this group.…”

Section: Resultsmentioning

confidence: 99%

Impact of Living Kidney Donation on Long-Term Renal and Patient Survival: An Evolving Paradigm

Mjøen

Holdaas

2014

Curr Transpl Rep

View full text Add to dashboard Cite

During the last decades, there have been several studies reporting the outcome after living kidney donation. These studies have not shown any increase in mortality or end-stage renal disease. This is reassuring for potential donors. However, in these studies, kidney donors have been compared with unselected general population controls. In recent studies, kidney donors have been compared with selected healthy controls designed to simulate the donor selection process and improve quantification of the attributable impacts of donation. Also, recent studies describe donor cohorts with a longer follow-up. One of these studies found increased mortality risk, and several studies have found increased risk of end-stage renal disease occurring several years after donation. These findings have consequences for how we evaluate and select living donors. Future studies on mortality and end-stage renal disease in donors should focus on large donor cohorts with a long follow-up and appropriate healthy control groups. Cross sectional studies performed months or years after donation should focus on comparisons with controls who were healthy at the time of the donor`s evaluation. Although recent studies have indicated attributable risks compared with healthy controls, absolute event rates of end-stage renal disease and/or mortality appear fairly low. Although these studies have modified our assessment of donor risk, we still promote living kidney donation.

show abstract

Familial Clustering of ESRD in the Norwegian Population

Cited by 83 publications

References 23 publications

Renal Function Profile in White Kidney Donors: The First 4 Decades

Renal Function Profile in White Kidney Donors: The First 4 Decades

The Irish Kidney Gene Project - Prevalence of Family History in Patients with Kidney Disease in Ireland

Impact of Living Kidney Donation on Long-Term Renal and Patient Survival: An Evolving Paradigm

Contact Info

Product

Resources

About