Familial carpal-tunnel syndrome presenting in childhood. Report of two cases.

Is there a familial carpal tunnel syndrome? An evaluation and literature review

“…4,7,9,10,[13][14][15]26 Six reports were reviewed with particular attention to gender, age of onset, and bilateral versus unilateral CTS. 4,7,9,10,13,15 Data were available for 55 out of 59 patients, of whom 65.5% were female; mean age at onset was 27.3 years, with 32.7% at age 20 years or earlier; and 96.3% had bilateral involvement. For the patients who underwent surgical release, pathologic examination showed thickening of the flexor retinaculum and tendon sheaths, with no evidence of amyloid or other known infiltrative process.…”

Primary Familial Carpal Tunnel Syndrome with Long-term Followup: A Study of Two Families and Review of the Literature

“…Electrodiagnostic testing reveals the typical median nerve neuropathy [1,2,19]. Intra-operatively, a narrow carpal tunnel and/or thickened transverse carpal ligament are frequently observed, as was seen in our first two patients [2,4,10,15,18,[20][21][22] [28].…”

“…Phalen's test was positive at the most small FCTS case series have been published. However, essentially all of these studies lack outcome measures beyond five years postoperatively [2,4,[8][9][10][11][12]. In addition, there are few reports noting outcomes in children afflicted with this condition.…”

Familial primary carpal tunnel syndrome with possible skipped generation

“…None of the secondary causes were found to be present in our patient after appropriate investigation. Familial CTS is a rare autosomal dominant disorder ( Table 2) with nearly full penetrance [1,[6][7][8]. However, no genes or loci have been identified so far [3].…”