Familial Benign Chronic Neutropenia Associated With Periodontal Disease: A Case Report

Deasy, Michael J.; Vogel, Richard I.; Macedo-Sobrinho, Braz; Gertzman, Gloria; Simon, B

doi:10.1902/jop.1980.51.4.206

Cited by 45 publications

(28 citation statements)

References 13 publications

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“…Not all neutropenias result in periodontal disease. Familial benign chronic neutropenia has variable expressivity and although several individuals within a family may be neutropenic, not all are affected by recurrent infections or periodontal disease (34). These findings might be explained by the variable genetic expression of the disorder or by the variable effects of the environment (such as plaque or smoking) on these patients.…”

Section: Evidence For the Role Of Genetic Variants In Periodontitismentioning

confidence: 99%

The genetic basis of periodontitis

Kinane¹,

Shiba²,

Hart³

2005

Periodontology 2000

167

162

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Section: Evidence For the Role Of Genetic Variants In Periodontitismentioning

confidence: 99%

The genetic basis of periodontitis

Kinane¹,

Shiba²,

Hart³

2005

Periodontology 2000

167

162

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“…Oral manifestations of chronic benign neutropenia include hyperplastic, edematous, and fiery‐red gingiva with areas of desquamation (6). Deasy described a 14‐year‐old boy with chronic benign neutropenia who was referred due to severe gingival inflammation, hyperplastic papillae, isolated areas of gingival recession, and a molar furcal lesion (51). Reichart et al.…”

Section: Chronic Neutropeniasmentioning

confidence: 99%

Systemic disease and periodontitis: manifestations of neutrophil dysfunction

Deas¹,

Mackey²,

McDonnell³

2003

Periodontology 2000

122

132

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“…Deasy et al 20 described a family exhibiting familial benign chronic neutropenia. They showed that, although several individuals within this family were neutropenic, not all were affected either by recurrent infections or by inflammatory periodontal disease.…”

Section: Quantitative Leucocyte Disorders Neutropeniamentioning

confidence: 99%

Peridonatal manifestations of systemic disease

Kinane

Marshall²

2001

Australian Dental Journal

140

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Periodontitis is a chronic bacterial infection of the supporting structures of the teeth. The host response to infection is an important factor in determining the extent and severity of periodontal disease. Systemic factors modify periodontitis principally through their effects on the normal immune and inflammatory mechanisms.Several conditions may give rise to an increased prevalence, incidence or severity of gingivitis and periodontitis. The effects of a significant number of systemic diseases upon periodontitis are unclear and often it is difficult to causally link such diseases to periodontitis. In many cases the literature is insufficient to make definite statements on links between certain systemic factors and periodontitis and for several conditions only case reports exist whereas in other areas an extensive literature is present.A reduction in number or function of polymorphonuclear leukocytes (PMNs) can result in an increased rate and severity of periodontal destruction. Medications such as phenytoin, nifedipine, and cyclosporin predispose to gingival overgrowth in response to plaque and changes in hormone levels may increase severity of plaqueinduced gingival inflammation. Immuno‐suppressive drug therapy and any disease resulting in suppression of the normal inflammatory and immune mechanisms (such as HIV infection) may perdispose the individual to periodontal destruction. There is convincing evidence that smoking has a detrimental effect on periodontal health. The histiocytoses diseases may present as necrotizing ulcerative periodontitis and numerous genetic polymorphisms relevant to inflammatory and immune processess are being evaluated as modifying factors in periodontal disease. Periodontitis severity and prevalence are increased in diabetics and worse in poorly controlled diabetics. Periodontitis may exacerbate diabetes by decreasing glycaemic control. This indicates a degree of synergism between the two diseases. The relative risk of cardiovascular disease is doubled in subjects with periodontal disease. Periodontal and cardiovascular disease share many common risk and socio‐economic factors, particularly smoking, which is a powerful risk factor for both diseases. The actual underlying aetiology of both diseases is complex as are the potential mechanisms whereby the diseases may be causally linked. It is thought that the chronic inflammatory and microbial burden in periodontal disease may predispose to cardiovascular disease in ways proposed for other infections such as with Chlamydia pneumoniae. To move from the current association status of both diseases to causality requires much additional evidence.Determining the role a systemic disease plays in the pathogenesis of periodontal disease is very difficult as several obstacles affect the design of the necessary studies. Control groups need to be carefully matched in respect of age, gender, oral hygiene and socio‐economic status. Many studies, particularly before the aetionlogical importance of dental plaque was recognised, failed to include such controls. Longitudinal studies spanning several years are preferable in individulas both with and without systemic disease, due to the time period in which periodontitis will develop.

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Familial Benign Chronic Neutropenia Associated With Periodontal Disease: A Case Report

Abstract: A rare case report of periodontal disease associated with familial benign chronic neutropenia is presented. The medical, dental and family histories as well as clinical and histologic observations are described and discussed.

Cited by 45 publications

References 13 publications

The genetic basis of periodontitis

The genetic basis of periodontitis

Systemic disease and periodontitis: manifestations of neutrophil dysfunction

Peridonatal manifestations of systemic disease

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