Familial Autoimmune Thyroid Disease as a Risk Factor for Regression in Children with Autism Spectrum Disorder: A CPEA Study

Molloy, Cynthia A.; Morrow, Ardythe L.; Meinzen‐Derr, Jareen; Dawson, Geraldine; Bernier, Raphael; Dunn, Michelle; Hyman, Susan; McMahon, William M.; Goudie-Nice, Julie; Hepburn, Susan; Minshew, Nancy J.; Rogers, Sally J.; Sigman, Marian; Spence, M. Anne; Tager–Flusberg, Helen; Volkmar, Fred R.; Lord, Catherine

doi:10.1007/s10803-005-0071-0

Cited by 101 publications

(63 citation statements)

References 41 publications

(47 reference statements)

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“…Comi et al (13) reported an increased incidence of autoimmune diseases in mothers of patients with autism compared with control mothers. A recently reported link between autism and autoimmune thyroid disorder increases the likelihood of finding some shared autoimmune etiologic process (14). Furthermore, autoantibodies implicated in autoimmune thyroid disorders are found with an increased prevalence in patients with type 1 diabetes (15)(16)(17).…”

Section: Results -Of 984 Individual Children With Diabetes Seen In Oumentioning

confidence: 99%

Type 1 Diabetes and Autism

2005

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Section: Results -Of 984 Individual Children With Diabetes Seen In Oumentioning

confidence: 99%

Type 1 Diabetes and Autism

2005

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“…87 Prospective studies have revealed that, except for a few individuals with recurrent infections, healthy children with ASDs generally have normal immune function. 135 Some studies have reported increased rates of autoimmune disorders in families of children with ASDs, 136 particularly in the mothers (eg, thyroid disorders 137 and psoriasis 138 ); however, the relevance of these common disorders to ASDs in children is unknown. Furthermore, studies have shown no increase in autoimmune disorders of the central nervous system, and patients with ASDs did not themselves exhibit autoimmune disorders.…”

Section: Table 2 Diagnostic Criteria For 29980: Asperger's Disorder mentioning

confidence: 99%

Identification and Evaluation of Children With Autism Spectrum Disorders

Johnson

Myers²

2007

Pediatrics

1,626

1,038

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Autism spectrum disorders are not rare; many primary care pediatricians care for several children with autism spectrum disorders. Pediatricians play an important role in early recognition of autism spectrum disorders, because they usually are the first point of contact for parents. Parents are now much more aware of the early signs of autism spectrum disorders because of frequent coverage in the media; if their child demonstrates any of the published signs, they will most likely raise their concerns to their child's pediatrician. It is important that pediatricians be able to recognize the signs and symptoms of autism spectrum disorders and have a strategy for assessing them systematically. Pediatricians also must be aware of local resources that can assist in making a definitive diagnosis of, and in managing, autism spectrum disorders. The pediatrician must be familiar with developmental, educational, and community resources as well as medical subspecialty clinics. This clinical report is 1 of 2 documents that replace the original American Academy of Pediatrics policy statement and technical report published in 2001. This report addresses background information, including definition, history, epidemiology, diagnostic criteria, early signs, neuropathologic aspects, and etiologic possibilities in autism spectrum disorders. In addition, this report provides an algorithm to help the pediatrician develop a strategy for early identification of children with autism spectrum disorders. The accompanying clinical report addresses the management of children with autism spectrum disorders and follows this report on page 1162 [available at www.pediatrics.org/cgi/content/full/120/5/1162]. Both clinical reports are complemented by the toolkit titled “Autism: Caring for Children With Autism Spectrum Disorders: A Resource Toolkit for Clinicians,” which contains screening and surveillance tools, practical forms, tables, and parent handouts to assist the pediatrician in the identification, evaluation, and management of autism spectrum disorders in children.

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“…188 Because these elevated autoantibodies were also present in at least one parent of children with autism, parental antibodies may contribute to autism etiology. 189 Two cohort studies and a case-control study found an association between maternal or family history of autoimmune diseases and ASD 124,190 or autistic regression, 191 whereas another case-control study found no association. 192 However, the specific autoimmune diseases associated with ASD varied by study.…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003–2013

Montigny

Ofner

et al. 2017

Health Promot Chronic Dis Prev Can

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Introduction: The number of children diagnosed with autism spectrum disorder (ASD) has been rapidly rising in the past decade. The etiology of this disorder, however, is largely unknown, although the environmental relative to the genetic contribution is substantial. We conducted a scoping review to comprehensively assess the current state of knowledge of the environmental factors present from preconception to early life associated with ASD, and to identify research gaps.

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Familial Autoimmune Thyroid Disease as a Risk Factor for Regression in Children with Autism Spectrum Disorder: A CPEA Study

Cited by 101 publications

References 41 publications

Type 1 Diabetes and Autism

Type 1 Diabetes and Autism

Identification and Evaluation of Children With Autism Spectrum Disorders

Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003–2013

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