Familial associations in women with polycystic ovary syndrome

Atiomo, William; Elmahdi, Essam; Hardiman, Paul

doi:10.1016/s0015-0282(03)00502-8

Cited by 42 publications

(21 citation statements)

References 4 publications

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“…Therefore, the result of our study revealed that breast cancer in the relatives of infertile population (without PCOS) was significantly higher than PCOS patients. Our results are inconsistent with the results of Atiomo and Hunter studies [8,9]. These disparities may be due to the small sample size of tested group in the Atiomo study, genetic in origin or intrauterine and environmental factors.…”

Section: Discussioncontrasting

confidence: 99%

“…One investigation by Atiomo et al showed a positive association between PCOS and family history of breast cancer and heart disease [8]. Another study by Hunter et al, conducted to measure the prevalence of heart disease, stroke, diabetes and associated risk factors among fathers and brothers of women with PCOS, revealed that the brothers of these women may be at an increase risk of CVD [9].…”

Section: Introductionmentioning

confidence: 99%

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Familial associations between polycystic ovarian syndrome and common diseases

Moini

Eslami

2009

J Assist Reprod Genet

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Familial associations between polycystic ovarian syndrome and common diseases

Moini

Eslami

2009

J Assist Reprod Genet

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“…It is interesting that four of the five women with high levels of OE2 had a family history of breast cancer. However, this is a very small sample and previous studies do not uniformly support a relationship between PCO and breast cancer (Atiomo et al 2003, Pierpoint et al 1998, Anderson et al 1997.…”

Section: Discussioncontrasting

confidence: 57%

Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women

Chatterton¹,

Mateo²,

Hou³

et al. 2005

Journal of Endocrinology

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The objective of the study was to characterize salivary sex steroid levels in 56 women undergoing annual mammography who were participating in a breast density study at the Lynn Sage Breast Center of Northwestern Memorial Hospital, and to determine the predictability of the patterns within women. Saliva was collected daily by the women at home for one complete menstrual cycle and then again at approximately 6-month intervals. The occurrence of sporadic anovulatory cycles was identified in 12 subjects, and persistent oestradiol (OE2) elevation in all three cycles without significant progesterone levels occurred in another five subjects. In addition, both OE2 and progesterone were significantly lower in initial menstrual cycles than in subsequent cycles, suggestive of an effect of participation in the study on hormone levels. Initial salivary OE2 levels were not good predictors of corresponding levels in either follicular or luteal phases of the menstrual cycles at the 6-month intervals. However, after the initial cycle, progesterone levels were highly predictable within individuals over a period of 6 months (r=0·78, P<0·001). The study emphasizes the natural variation among and within women in the absence of any intervention, and indicates the need for properly controlled studies before attributing changes in hormonal levels to therapy. In addition, it emphasizes the importance of sampling at multiple time points when examining the relationship between hormones and risk.

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“…Before the commencement of this study, although studies had looked at the prevalence of CVD and diabetes in the relatives of women with PCOS (Azziz and Kashar-Miller 2000;Mao et al 2000;Benitez et al 2001Kaushal et al 2004Yildiz et al 2003;Atiomo et al 2003), suggesting an increased prevalence of metabolic disorders and heart disease, only one study focussed primarily on male relatives (Kaushal et al 2004). In the study, which was limited to women of Asian origin, the brothers of 40 women with PCOS were found to have an increased incidence of insulin resistance comparable with that associated with those with a family history of type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

To determine whether first-degree male relatives of women with polycystic ovary syndrome are at higher risk of developing cardiovascular disease and type II diabetes mellitus

Hunter

Vimplis

Sharma

et al. 2007

Journal of Obstetrics and Gynaecology

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The aim of this study was to determine whether first-degree male relatives of women with polycystic ovary syndrome (PCOS) were at increased risk of cardiovascular disease (CVD) and diabetes mellitus (type II DM). In a cross-sectional study, 60 women with PCOS and 112 controls were given a questionnaire. The prevalence of heart disease, stroke, diabetes and associated risk factors among fathers and brothers of women with PCOS and controls, were measured. The percentage of women with PCOS with at least one brother with a risk factor for CVD was 47.5%, around twice that seen in control women (24.71%). The prevalence of heart disease, stroke and diabetes were similar in brothers of women with PCOS and controls. In conclusion, brothers of women with PCOS may be at increased risk of CVD. They form an easily identified group, which can be targeted for primary prevention.

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Familial associations in women with polycystic ovary syndrome

Cited by 42 publications

References 4 publications

Familial associations between polycystic ovarian syndrome and common diseases

Familial associations between polycystic ovarian syndrome and common diseases

Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women

To determine whether first-degree male relatives of women with polycystic ovary syndrome are at higher risk of developing cardiovascular disease and type II diabetes mellitus

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