Familial and Sporadic Inflammatory Bowel Disease: Different Entities?

Peeters, Marc; Cortot, Antoine; Vermeire, Séverine; Colombel, Jean–Frédéric

doi:10.1097/00054725-200011000-00008

Cited by 31 publications

(16 citation statements)

References 52 publications

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“…Until now, no evidence has been found to allow investigators to assume that sporadic and familial IBD are different entities. 29 Neither ASCAs nor perinuclear anti‐neutrophil cytoplasmic antibodies were associated with the familial presence of the disease in the study by Halme et al 30 In the present study, however, we found an association of ASCAs with familial disease.…”

Section: Discussioncontrasting

confidence: 81%

Pancreatic Autoantibodies in Inflammatory Bowel Disease

Joossens¹,

Vermeire²,

Steen

et al. 2004

Inflammatory Bowel Diseases

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Section: Discussioncontrasting

confidence: 81%

Pancreatic Autoantibodies in Inflammatory Bowel Disease

Joossens¹,

Vermeire²,

Steen

et al. 2004

Inflammatory Bowel Diseases

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“…The results reported here also extend the hypothesis that there is a subgroup of CD patients with colonic disease which may be defined by the presence of a unique serum marker profile (48) and now the genetic marker HLA DRB1*0103 (in contrast to the association of NOD2/CARD15 with ileal CD (44)). Taken together, these data as well as clinical data suggesting that colonic CD may have different epidemiological (47) features and treatment responses (49) support the concept that colonic CD may be a unique form of IBD with divergent etiologic contributors. These data also confirm the importance of clinical phenotyping and the value of subgroup analyses as aids to further delineate the genetic factors contributing to IBD.…”

Section: Discussionsupporting

confidence: 58%

“…Similarly, insufficient sample size or lack of clinical information may have interfered with discovery of the relationship between HLA DRB1*0103 and colonic involvement in CD in previous studies. The relatively few patients in this study with colonic CD is likely reflective of the fact that the group studied here is a familial IBD population in which the prevalence of colonic CD appears to be lower than in sporadic cases of CD (47).…”

Section: Discussionmentioning

confidence: 94%

A Population- and Family-Based Study of Canadian Families Reveals Association of HLA DRB1*0103 With Colonic Involvement in Inflammatory Bowel Disease

Silverberg¹,

Mirea

Bull

et al. 2003

Inflammatory Bowel Diseases

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The aim of this study was to identify major histocompatibility complex alleles associated with the development and clinical features of inflammatory bowel disease (IBD). Genotyping at the human leukocyte antigen (HLA) DRB1 and DQB1 loci was performed on individuals from 118 Caucasian IBD sibling pair families and on 216 healthy controls. Both population- and family-based association tests were used to analyze data obtained on the entire study population and on clinical subgroups stratified by diagnosis, ethnicity, and disease distribution. HLA DRB1*0103 was significantly associated with IBD (OR = 6.0, p = 0.0001) in a case-control analysis of non-Jewish IBD-affected individuals. This association was apparent among both Crohn's disease (OR = 5.23, p = 0.0007) and ulcerative colitis (OR = 7.9, p = 0.0001) patients and was confirmed in the non-Jewish IBD population by results of family-based association analysis using the transmission disequilibrium test. HLA DQB1*0501 was also associated with IBD (OR = 1.64, p = 0.02) in the non-Jewish population. but statistically significant association of this allele with disease was not detected for Crohn's disease and ulcerative colitis separately. No significant associations were identified among the Jewish patients. In the non-Jewish IBD families, IBD was as strongly associated with the DRB1*0103 DQB1*0501 haplotype as with the DRB1*0103 allele alone. The carrier frequency of the DRB1*0103 allele was found to be 10-fold higher in Crohn's disease patients with pure colonic involvement than in healthy controls (38.5% vs. 3.2%; p = 0.0002). These data demonstrate the association of the HLA DRB1*0103 allele with both Crohn's disease and ulcerative colitis and with large intestine-restricted disease in non-Jewish IBD patients and therefore identify HLA DRB1*0103 as a potentially important contributor to disease susceptibility and to expression of colonic involvement in IBD.

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“…This finding is consistent with previous studies demonstrating a familial aspect of IBD [9,15,19]. A cohort study from six pediatric centres in the United States by Heyman et al reported a positive family history of IBD to be more common in UC patients [20].…”

Section: Discussionsupporting

confidence: 91%

“…demonstrated the presence of non-random overlapping of susceptibility loci among autoimmune diseases such as multiple sclerosis (MS), CD, psoriasis, asthma and type I diabetes (IDDM) [5]. Furthermore, there is considerable evidence that other immune-related disorders may be associated with bronchial asthma and rheumatoid arthritis [6-9]. …”

Section: Introductionmentioning

confidence: 99%

Immune-related disorders in families of children with inflammatory bowel disease - A prospective cohort study

2011

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BackgroundThe aim of this paper was to examine the prevalence of immune-related disorders in families of children with inflammatory bowel disease (IBD) compared to those without IBD.MethodsChildren ≤18 years of age presenting to the IBD clinic between September 2007 and August 2009 with an established diagnosis of IBD were recruited. Age and sex matched controls without IBD were recruited. The study was a single-centre prospective cohort study. Outcome measures were prevalence of immune-based/inflammatory diseases in families of both patients and controls.ResultsOne hundred and eight children in each group were recruited. Asthma was the most frequently reported disease in families of the IBD patients (52.8%) and controls (46.3%). The prevalence of IBD in families of IBD patients was significantly higher than in those without IBD (OR 2.03, 95% CI 1.04-3.95).ConclusionsThe prevalence of immune-based disorders, as a group, in families of children with IBD was not significantly higher when compared to children without IBD.

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Familial and Sporadic Inflammatory Bowel Disease: Different Entities?

Cited by 31 publications

References 52 publications

Pancreatic Autoantibodies in Inflammatory Bowel Disease

Pancreatic Autoantibodies in Inflammatory Bowel Disease

A Population- and Family-Based Study of Canadian Families Reveals Association of HLA DRB1*0103 With Colonic Involvement in Inflammatory Bowel Disease

Immune-related disorders in families of children with inflammatory bowel disease - A prospective cohort study

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