Familial Aggregation of Psoriasis and Co-Aggregation of Autoimmune Diseases in Affected Families

Abstract

Psoriasis is considered to result from the interaction of genetic factors and environmental exposure. The evidence for familial aggregation in psoriasis has been reported but population-based studies related to the magnitude of genetic contribution to psoriasis are rare. This study aimed to evaluate the relative risks of psoriasis in individuals with affected relatives and to calculate the proportion of genetic, shared, and non-shared environmental factors contributing to psoriasis. The study cohort included 69,828 patients diagnosed with psoriasis enrolled in National health Insurance in 2010. The adjusted relative risks (RR) for individuals with an affected first-degree relative and affected second-degree relative were 5.50 (95% CI (Confidence Interval), 5.19–5.82) and 2.54 (95% CI, 2.08–3.12) respectively. For those who have affected first-degree relatives, their RR was 1.45 (95% CI, 1.17–1.79) for Sjogren’s syndrome and 1.94 (95% CI, 1.15–3.27) for systemic sclerosis. This nationwide study ascertains that family history of psoriasis is a risk factor for psoriasis. Individuals with relatives affected by psoriasis have higher risks of developing some autoimmune diseases.

The current landscape of psoriasis genetics in 2020

“…Psoriasis is a multifactorial genetic disease for which the genetic factors explain about 70 % of disease susceptibility [9]. A higher incidence of psoriasis within families has been reported worldwide [10]. In twin studies, monozygotic twins have a susceptibility to psoriasis that is 2-3 times higher than that of double zygotic twins [9].…”

Inflammatory bowel disease and psoriasis: modernizing the multidisciplinary approach

“…One of the greatest risk factors for developing IBD is having a first-degree relative with IBD [24,25], with the risk of developing IBD in siblings of patients with CD around 5% [26]. Similarly, the lifetime risk of psoriasis increases with the number of affected relatives, being 25 % with one affected sibling or parent and up to 50% with 2 affected close relatives [27]. Both IBD and psoriasis are more common in people of European ancestry [28,29].…”

Transcriptomic landscaping of core genes and pathways of mild and severe psoriasis vulgaris

“…It is a multifactorial disease (2), with both genetic and environmental factors contributing to its development. Beyond its dermatological manifestations, psoriasis has a negative impact on the quality of life of affected subjects and has been found to be an independent risk factor for cardiovascular diseases, psoriatic arthritis, atherosclerosis, diabetes and insulin resistance, hypertension, metabolic syndrome, myocardial infarction and obesity, which cause an immense disease burden on patients (3)(4)(5)(6).…”