Familial aggregation of astrocytoma in northern Sweden: An epidemiological cohort study

Malmer, Beatrice; Grönberg, Henrik; Bergenheim, A. Tommy; Lenner, Per; Henriksson, Roger

doi:10.1002/(sici)1097-0215(19990505)81:3<366::aid-ijc9>3.0.co;2-0

Cited by 83 publications

(62 citation statements)

References 16 publications

(16 reference statements)

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“…As a criterion for accepting a family into the study, at least 2 gliomas per family were required, whereas in most previous studies, families with at least 1 glioma were eligible. [5][6][7][8][9][10][11] In our study, the diluting effect of families with sporadic gliomas is reduced and, therefore, the possibility of detecting cancers associated with hereditary gliomas is increased. The strategy of investigating families with 2 or more gliomas reduces the number of families to be studied but the size of the family is expanded when relatives beyond first-degree are included.…”

Section: Discussionmentioning

confidence: 58%

“…27 The familial occurrence of brain tumors has been confirmed in several epidemiological studies. [5][6][7][8][9] About 4% (11/297) of glioma patients have been shown to have first-degree relatives affected with verified gliomas, which is statistically significantly more than the expected incidence of sporadic gliomas. 8 Our study, investigating pedigrees ranging beyond first-degree relatives, showed that about 9% (30/317) of glioma patients have relatives with gliomas.…”

Section: Discussionmentioning

confidence: 98%

“…[3][4][5][6][7][8][9] In the present study, occurrence of other cancers in families affected with 2 or more gliomas was examined with epidemiological population-based study design. As a criterion for accepting a family into the study, at least 2 gliomas per family were required, whereas in most previous studies, families with at least 1 glioma were eligible.…”

Section: Discussionmentioning

confidence: 99%

“…2 Furthermore, families with multiple gliomas but without obvious connection to known tumour syndromes have been described in several case reports 3,4 and epidemiological studies. [5][6][7][8][9] Our aim was to clarify which other cancers might occur in excess in families affected with 2 or more gliomas. Although a number of epidemiological studies on glioma families have been reported, association with other types of cancer has remained obscure because earlier results have been inconsistent.…”

mentioning

confidence: 99%

“…Although a number of epidemiological studies on glioma families have been reported, association with other types of cancer has remained obscure because earlier results have been inconsistent. [5][6][7][8][9][10][11][12] Therefore, in the present study, the possibility that more than 1 tumour syndrome may involve pedigrees with multiple glioma patients was examined. Unlike most earlier epidemiological studies investigating families with 1 or more gliomas, [5][6][7][8][9][10][11] we focused on families affected with at least 2 verified gliomas.…”

mentioning

confidence: 99%

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Cancer incidence in families with multiple glioma patients

Paunu

Pukkala

Laippala

et al. 2001

Intl Journal of Cancer

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Twenty-four Finnish families with 2 or more glioma patients were identified through questionnaires sent to 369 consecutive glioma patients receiving surgery at Tampere University Hospital during 1983-94. To explore whether unusual cancer susceptibility is involved, the cancer risk of 2,664 family members was estimated using population-based data from the Finnish Cancer Registry. Among the total cohort of relatives, 88 cancers were observed during 1953-97. The overall cancer risk among 12 families with juvenile onset gliomas was significantly decreased (standardized incidence ratio [SIR] 0.6, 95% confidence interval [CI]: 0.4 -0.9). Among 12 families with adult onset gliomas, the overall cancer risk was equal to that of the reference population (SIR 1.1, 95% CI: 0.8 -1.4) whereas the risk of skin melanoma (SIR 4.0, 95% CI: 1.5-8.8) and meningioma (SIR 5.5, 95% CI: 1.1-16) were significantly increased. Several other tumors, including those associated with neurofibromatosis 1 and 2, tuberous sclerosis and Li-Fraumeni and Turcot syndromes were surveyed, but no elevated risks were observed. In conclusion, the presence of meningiomas and skin melanomas in glioma families may indicate a novel association as a cancer susceptibility trait.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cancer incidence in families with multiple glioma patients

Paunu

Pukkala

Laippala

et al. 2001

Intl Journal of Cancer

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Primary brain tumours as second primary: A novel association between meningioma and colorectal cancer

et al. 2000

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Segregation analysis of cancer in families of glioma patients

et al. 2001

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A small proportion of brain tumors are attributed to a genetic predisposition; however, the hereditary proportion is undetermined. This study evaluates the degree of familial aggregation of cancer in a large series of brain tumor patients. Our study included 5,088 relatives of 639 probands (3,810 first‐ and 1,278 second‐degree), diagnosed with a glioma between June 1992 and June 1995 at The University of Texas M. D. Anderson Cancer Center, Houston, Texas, with diagnosis under age 65 years, and residents of the United States or Canada. We conducted an in‐person or telephone interview with patients and/or their next‐of‐kin, and obtained family histories for the probands’ first‐degree (parents, siblings, offspring) and selected second‐degree relatives (aunts, uncles, grandparents) using a sequential sampling strategy. Reported cancers were documented by medical records and/or death certificates (if the relative was deceased and medical records were unavailable). We conducted segregation analysis using the Pedigree Analysis Program (PAP). The analyses were divided into two categories: (1) all 639 families, and (2) a subset of families whose gliomas stained positive on p53 immunohistochemistry analysis. We demonstrated that a multifactorial Mendelian model was favored, while a model postulating a purely environmental cause of brain cancer was rejected. This study indicates that familial cancer in relatives of glioma patients are probably a result of multigenic action, and familial clustering of cancer among relatives of glioma patients may involve unknown environmental exposures. Genet. Epidemiol. 20:258–270, 2001. © 2001 Wiley‐Liss, Inc.

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Familial aggregation of astrocytoma in northern Sweden: An epidemiological cohort study

Cited by 83 publications

References 16 publications

Cancer incidence in families with multiple glioma patients

Cancer incidence in families with multiple glioma patients

Primary brain tumours as second primary: A novel association between meningioma and colorectal cancer

Segregation analysis of cancer in families of glioma patients

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