Familial Aggregation of Alzheimer's Disease and Related Disorders: A Collaborative Re-Analysis of Case-Control Studies

Duijn, Cornelia M. van; Clayton, David; Chandra, V; Fratiglioni, Laura; Graves, Amy Borenstein; Heyman, Albert; Jorm, Anthony F; Kokmen, Emre; Kondo, Kiyotaro; Mortimer, James A.; Rocca, Walter A.; Shalat, Stuart L.; Soininen, H.; Hofman, Albert

doi:10.1093/ije/20.supplement_2.s13

Cited by 178 publications

(99 citation statements)

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“…A population-based case-control study reported higher frequency of first-degree relatives with PD among Alzheimer's patients than among controls, corresponding to a RR of 2.9 [572]. Re-analysis of these data pooled with data from another study [573] gave similar results (RR 2.4, 95% CI 1.0-5.8) [574]. Other studies, however, reported no increased risk of PD in relatives of patients with Alzheimer's disease [575][576][577][578], although two of these were small, including only 70 [576] and 98 [577] Alzheimer cases.…”

Section: Dementiamentioning

confidence: 79%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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Section: Dementiamentioning

confidence: 79%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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“…49,50 In a small number of families there is autosomal dominant transmission for AD manifesting in middle age. 49 Almost all Down syndrome patients over the age of 40 have neuropathological changes typical of Alzheimer's disease.…”

Section: Genetics Of Dementiamentioning

confidence: 99%

The Recognition, Assessment and Management of Dementing Disorders: Conclusions from the Canadian Consensus Conference on Dementia

Patterson

Grek

Gauthier

et al. 2001

Can. J. Neurol. Sci.

122

119

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To develop evidence based consensus statements on which to build clinical practice guidelines for primary care physicians towards the recognition, assessment and management of dementing disorders; ii) to disseminate and evaluate the impact of these statements and guidelines built on these statements. O p t i o n s : Structured approach to assessment, including recommended laboratory tests, choices for neuroimaging and referral; management of complications (especially behaviour problems and depression) and use of cognitive enhancing agents. Potential outcomes: Consistent and improved clinical care of persons with dementia; cost containment by more selective use of laboratory investigations, neuroimaging and referrals; appropriate use of cognitive enhancing agents. E v i d e n c e : Authors of each background paper were entrusted to: perform a literature search, discover additional relevant material including references cited in retrieved articles; consult with other experts in the field and then synthesize information. Standard rules of evidence were applied. Based upon this evidence, consensus statements were developed by a group of experts, guided by a steering committee of eight individuals from the areas of Neurology, Geriatric Medicine, Psychiatry, Family Développer des énoncés consensuels basés sur les données actuelles de la science sur lesquels on puisse construire des lignes directrices cliniques pour les médecins de première ligne pour l'identification, l'évaluation et la prise en charge des patients déments; ii) diffuser et évaluer l'impact de ces énoncés et des lignes directrices basées sur ces énoncés. O p t i o n s : Une approche structurée pour l'évaluation, incluant les épreuves de laboratoire recommandées, les choix d'examens de neuroimagerie et de référence en spécialité; la prise en charge des complications (spécialement des problèmes de comportement et de dépression) et l'utilisation d'agents qui améliorent la fonction cognitive. Bénéfices potentiels: Des soins améliorés et fiables aux personnes démentes; un contrôle des coûts par une utilisation plus judicieuse des examens de laboratoire, de la neuroimagerie et de la référence en spécialité; une utilisation appropriée des agents qui améliorent la fonction cognitive. É v i d e n c e : Les auteurs de chaque article de fond ont reçu le mandat de faire une recherche de la littérature pour ajouter des informations pertinentes incluant les références citées dans ces articles; consulter d'autres experts dans ce domaine et faire une synthèse de l'information. Ces tâches ont été effectuées conformément aux normes de la preuve. Sur la foi de cette évidence, les énoncés consensuels ont été développés par un groupe d'experts, guidé par un comité de direction de huit individus des domaines de la neurologie, de la gériatrie, de la psychiatrie, de la médecine familiale, de la médecine préventive et des systèmes de santé. Va l e u r s : Des recommandations ont été développées en portant une attention particulière sur le contexte des soins de première ligne ...

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“…One of the earliest reposted risk factors was positive family history (2), an indicator of possible genetic risk. These easly findings have not only been supported by linkage to a number of loci in families with early onset Alzheimer's disease (3)(4)(5), but also by case-referent studies of late onset cases (6,7) and twin studies assessing the relative importance of genetic and environmental effects for liability to the disease (8)(9)(10). In addition, genetic association studies suggest that some nonlinked loci may also increase susceptibility to Alzheimer's disease (1 1, 12) in persons of advanced age.…”

mentioning

confidence: 90%

Dementia and occupational exposure to magnetic fields

Feychting¹,

Pedersen²,

Svedberg³

et al. 1998

Scand J Work Environ Health

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Objectives The purpose of the present report was to assess whether occupational magnetic field exposure is a risk factor for dementia, in particular for Alzheimer's disease. Methods Case-control analyses were applied to 77 dementia cases, 55 of whom had Alzheimer's disease, ascertained from the population-based Swedish twin register. Two reference groups were derived, with 228 and 238 persons, respectively. Occupations were linked to a job-exposure matrix based on magnetic field measurements. Primary occupation, last occupation before reference date, and the occupation with the highest magnetic field exposure during the subject's lifetime were evaluated. Results For primary occupation, all relative risk estimates were close to unity. For last occupation, at the exposure level 2 0.2 KT, a relative risk was found for dementia estimated at 3.3 [95% confidence interval (95% CI) 1.3-8.61 and 3.8 (95% CI 1.4-10.2) for reference groups 1 and 2, respectively. The relative risk for Alzheimer's disease was estimated at 2.4 (95% CI 0.8-6.9) and 2.7 (95% CI 0.9-7.8), respectively. For the occupation with the highest magnetic field exposure, the relative risk estimates were close to unity for reference group 1 and slightly elevated for reference group 2. The relative risk estimates were greater for the subjects who were younger at onset (275 years). C O~C~U S~O~S These results only partially support previous findings, but they indicate that occupational magnetic field exposure may possibly influence the development of dementia.

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Familial Aggregation of Alzheimer's Disease and Related Disorders: A Collaborative Re-Analysis of Case-Control Studies

Cited by 178 publications

References 0 publications

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

The Recognition, Assessment and Management of Dementing Disorders: Conclusions from the Canadian Consensus Conference on Dementia

Dementia and occupational exposure to magnetic fields

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