Familial adenomatous polyposis in association with thyroiditis

Abstract

The authors report two patients with familial adenomatous polyposis and thyroiditis. One patient was discovered at autopsy to have in addition, a follicular carcinoma of the thyroid and focal nodular hyperplasia of the liver. The other patient had a sister with familial adenomatous polyposis and a papillary carcinoma of the thyroid. The association between familial adenomatous polyposis and thyroiditis has not been previously reported.

Is there a relationship between familial adenomatous polyposis and focal nodular hyperplasia?

“…Unlike these findings, in addition to the colonic adenomatous polyp, we also found β-catenin accumulation in FNH. To our knowledge, this is the second reported case of FNH in a patient with FAP 7. Moreover, development of FNH 5 years after total proctocolectomy for FAP combined with β-catenin accumulation in a male patient with FNH supports our suggestion that FNH may be an extracolonic manifestation of FAP.…”

Thyroid carcinoma associated with familial adenomatous polyposis

“…The probability that this inflammatory lesion could be a non-causal finding deserves further investigation. To our knowledge, there is only one other report describing non malignant or 'premalignant' thyroid lesions in two members of a FAP family, with relatives affected by thyroid carcinoma 24 . Both were females.…”

“…Both were females. Intralobular lymphoid infiltrate in the former patient (a 15-year-old girl) was reported as Hashimoto's thyroiditis, while in the latter, the lymphocytic infiltrate was associated with a small follicular carcinoma 24 .…”

Results of a prospective thyroid ultrasound screening program in adenomatous polyposis patients

“…24,25 In addition, TC has been shown to occur in a background of underlying benign thyroid disease. 12,26,27 One of the FAP patients diagnosed with TC was found to have PTC in the background of chronic thyroiditis. Further studies are necessary to validate whether this association observed in our small cohort suggests an increased TC risk in FAP patients with benign thyroid disease.…”