Familial Abnormalities in Adrenocortical Function

Androgens

“…Dr T M Barratt,1 Dr R W H Edwards, Mr H L J Makin and Dr B E Clayton (Institute ofChildHealth and Department of ChemicalPathology, Hospitalfor Sick Children, Great Ormond Street, London) Varieties of Adrenal Hyperplasia in Children Of all the virilizing syndromes of childhood, congenital adrenal hyperplasia is the commonest, best understood and perhaps, from a physiological standpoint, the most interesting. The present position has been recently reviewed by Stempfel & Franks (1963). There is a genetically determined failure of cortisol biosynthesis and ACTH production is maintained at a high level by a failure of feedback inhibition.…”