FAM19A5/S1PR1 signaling pathway regulates the viability and proliferation of mantle cell lymphoma

Wang, Yanfang; Zhang, Zhenhao; Wan, Wei; Liu, Yan; Jing, Hongmei; Dong, Fang

doi:10.1080/10799893.2021.1895220

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…Moreover, Yanfang Wang et al demonstrated that the FAM19A5/S1PR1 signaling pathway regulates mantle cell lymphoma viability and proliferation. 51 …”

Section: Fam19a5 Original Direction Of Researchmentioning

confidence: 99%

“…50 Moreover, Yanfang Wang et al demonstrated that the FAM19A5/S1PR1 signaling pathway regulates mantle cell lymphoma viability and proliferation. 51 N Sevane et al looked for reasons for the rapid livestock adaptation to extreme climatic conditions. They compared the methylomes of two Creole cattle breeds living in tropical environments with their putative Spanish ancestors.…”

Section: Fam19 -Other Research Directionsmentioning

confidence: 99%

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Can Adipokine FAM19A5 Be a Biomarker of Metabolic Disorders?

Wesołek-Leszczyńska,

Pastusiak,

Bogdański

et al. 2024

DMSO

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Aim One of the most critical functions of adipose tissue is the production of adipokines, ie, numerous active substances that regulate metabolism. One is the newly discovered FAM19A5, whose older name is TAFA-5. Purpose The study aimed to review the literature on the FAM19A5 protein. Methods The review was conducted in December 2023 using the PubMed (Medline) search engine. Sixty-four papers were included in the review. Results This protein exhibits the characteristics of an adipokine with positive features for maintaining homeostasis. The results showed that FAM19A5 was highly expressed in adipose tissue, with mild to moderate expression in the brain and ovary. FAM19A5 may also inhibit vascular smooth muscle cell proliferation and migration through the perivascular adipose tissue paracrine pathway. Serum levels of FAM19A5 were decreased in obese children compared with healthy controls. There are negative correlations between FAM19A5, body mass index, and fasting insulin. Serum FAM19A5 level is correlated with type 2 diabetes, waist circumference, waist-to-hip ratio, glutamic pyruvic transferase, fasting plasma glucose, HbA1c, and mean shoulder pulse wave velocity. FAM19A5 expression was reduced in mice with obesity. However, the data available needs to be clarified or contradictory. Conclusion Considering today’s knowledge about FAM19A5, we cannot consider this protein as a biomarker of the metabolic syndrome. According to current knowledge, FAM19A5 cannot be considered a marker of metabolic disorders because the results of studies conducted in this area are unclear.

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“…Moreover, Yanfang Wang et al demonstrated that the FAM19A5/S1PR1 signaling pathway regulates mantle cell lymphoma viability and proliferation. 51 …”

Section: Fam19a5 Original Direction Of Researchmentioning

confidence: 99%

Section: Fam19 -Other Research Directionsmentioning

confidence: 99%