False-positive ELISA reactivity to hepatitis B virus surface antigen (HBsAg)

Four cases of type 2 hepatitis B virus (HBV-2) infection were demonstrated in the Gizan area of Saudi Arabia during the hepatitis B marker ELISA screening of the 152 native pregnant females, 42 cases of primary hepatocellular carcinoma, 19 cases with an epithelial but non-hepatic malignancy, 16 with a non-epithelial and non-hepatic malignancy and eight with chronic hepatitis. HBV-2 infection diagnosis was based on HBsAg positivity without anti-HBc, anti-HBs and HBeAg in one pregnant female and one patient each with a primary hepatocellular carcinoma, lymphocytic lymphoma and metastatic adenocarcinoma. During neutralisation of HBsAg ELISA reactivity, the respective reduction in absorbance values in sera from the pregnant female and the patient with primary hepatocellular carcinoma were 21% and 76% respectively. HBV-2 specific gene probes would be needed to define its role in pathogenesis of malignant neoplasms and chronic hepatitis. Incorporation of pre-S2 sequences in future hepatitis B vaccines is likely to protect against both, HBV-2 and conventional hepatitis B (HBV-1) exposures.

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Type 2 hepatitis B virus (HBV-2) in carriers and patients with malignancy in Saudi Arabia

Arya

Pathak

Ashraf

1990

Infection

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Hepatitis D Virus and Human Immunodeficiency Virus Antibodies in Parenteral Drug Abusers Who Are Hepatitis B Surface Antigen Positive

Novick¹,

Farci²,

Croxson³

et al. 1988

Journal of Infectious Diseases

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We studied unselected, hepatitis B surface antigen (HBsAg)-positive parenteral drug abusers for antibody to hepatitis D virus (anti-HD) and antibody to human immunodeficiency virus (HIV). The prevalences of anti-HD and antibody to HIV were 67% and 58%, respectively, and there was no association between positivity for these two markers. In a logistic regression model, anti-HD was associated with older age (P = .001), longer duration of drug abuse (P = .045), and the presence of liver disease (P = .002). Antibody to HIV was associated with a younger age (P = .003) and increased serum globulin levels (P less than .001). In patients infected with HIV, the severity of hepatic dysfunction remained correlated with anti-HD. In anti-HD-positive patients, most indices of hepatic dysfunction were similar whether or not antibody to HIV was present, but serum aspartate aminotransferase levels were significantly higher in patients with both anti-HD and antibody to HIV. (124 +/- 16 vs. 74 +/- 11, P less than .05).

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False-positive ELISA reactivity to hepatitis B virus surface antigen (HBsAg)

Cited by 2 publications

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Type 2 hepatitis B virus (HBV-2) in carriers and patients with malignancy in Saudi Arabia

Type 2 hepatitis B virus (HBV-2) in carriers and patients with malignancy in Saudi Arabia

Hepatitis D Virus and Human Immunodeficiency Virus Antibodies in Parenteral Drug Abusers Who Are Hepatitis B Surface Antigen Positive

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