False-negative urine human chorionic gonadotropin in molar pregnancy: <sup>"</sup> The high-dose hook effect<sup>"</sup> !

Datti, Sujata Narendra; Ray, Payel; Dharmavijaya, Jayashree Ashok Kumar

doi:10.4103/0974-5009.157049

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2020

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“…Various clinicians have published like Datti SN. 5 et al reported a false negative pregnancy test in case of partial mole and choriocarcinoma, also Pang YP et al reported a false negative test in molar pregnancy. 4 Also similar case reports have been mentioned by Nalini et al who again reported it in molar pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Variant hook effect: A cause of false negative result in point of care testing

Singh¹,

Preethi²,

Batra³

et al. 2020

IJOGR

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Beta Human Chorionic Gonadotrophin (β hCG) assays are sandwich chromatographic immunoassays which give a false negative results at high hCG concentrations and also in the presence of variants of hCG like hyperglycosylated hCG and hCG core fragments. This is imperative in everyday clinical scenario as it delays the diagnosis of pregnancy and its related complications. We have discussed two such cases where in the first case the diagnosis of hydatidiform mole was delayed due hook effect whereas in the second case the diagnosis of GTD was missed because of variant hook effect.

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Section: Discussionmentioning

confidence: 99%