False-negative MRI breast screening in high-risk women

Maxwell, Anthony; Lim, Yit Yoong; Hurley, Edward J.; Evans, D. Gareth; Howell, Anthony; Gadde, Soujanya

doi:10.1016/j.crad.2016.10.020

Cited by 17 publications

(13 citation statements)

References 31 publications

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“…MRI has been shown to have high sensitivity for breast cancer detection [ 2 , 4 , 7 ], but false negatives do still occur. Technical difficulties, reader perception, and lesion characteristics are components that may be implicated in the non-detection of breast cancers on MRI studies.…”

Section: Discussionmentioning

confidence: 99%

“…The positioning of the patient is crucial in MRI studies of the breast, as inadequate positioning can result in the lesion being outside the coil and therefore not captured in the study [ 6 , 9 ]. A motion artefact may obscure small lesions, and therefore it is important to gently fixate the breasts and advise the patient to remain still during the scan [ 3 - 4 , 7 ]. Strong background enhancement can be problematic, as normal glandular tissue may show the same enhancement pattern as breast cancer [ 2 , 4 - 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The principle of tumor angiogenesis had previously led radiologists to assume that non-enhancing breast lesions were not malignant [ 4 - 6 ]. However recent studies have shown that MRI cannot be used as a single imaging modality for the evaluation of breast cancer, as false negative results can occur [ 2 - 5 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Large Non-enhancing Breast Cancer on Breast Magnetic Resonance Imaging: A Case Report

Peters¹,

Tsai²,

Peters³

2018

Cureus

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A 55-year-old female presented with vague symptoms in the lateral left breast. Digital breast tomosynthesis and breast ultrasound showed no focal lesion, and magnetic resonance imaging (MRI) was subsequently performed. No suspicious enhancement was seen on MRI; in particular, no suspicious lesion was seen in the area of clinical concern. In view of persisting focal mastalgia and vague parenchymal changes in the symptomatic area on repeat targeted ultrasound, a core biopsy was performed. Final pathology after left mastectomy with axillary clearance showed a 42 mm grade 2 invasive ductal carcinoma. Ten out of 15 lymph nodes contained metastatic carcinoma. This case report presents a large ductal breast cancer with no enhancement on breast MRI. Factors that may contribute to the non-detection of breast cancers on MRI studies will be discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Large Non-enhancing Breast Cancer on Breast Magnetic Resonance Imaging: A Case Report

Peters¹,

Tsai²,

Peters³

2018

Cureus

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“…The sensitivity of the MRI method for patients with BRCA1 gene expression was better than those with BRCA2 gene expression which was 92% and 58%, respectively, while the sensitivity was worse for mammography (23% and 50%, respectively). However, when MRI and mammography were used together, the sensitivity of breast cancer for both genes was 92% [33]. Another major challenge of MRI for breast imaging along with the high cost and time of the scan is patients' difficulties in maintaining proper posture.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

A review of various modalities in breast imaging: technical aspects and clinical outcomes

Iranmakani

Mortezazadeh

Sajadian

et al. 2020

Egypt J Radiol Nucl Med

121

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Background: Nowadays, breast cancer is the second cause of death after cardiovascular diseases. In general, about one out of eight women (about 12%) suffer from this disease during their life in the USA and European countries. If breast cancer is detected at an early stage, its survival rate will be very high. Several methods have been introduced to diagnose breast cancer with their clinical advantages and disadvantages. Main text: In this review, various methods of breast imaging have been introduced. Furthermore, the sensitivity and specificity of each of these methods have been investigated. For each of the imaging methods, articles that were relevant to the past 10 years were selected through electronic search engines, and then the most relevant papers were selected. Finally, about 40 articles were studied and their results were categorized and presented in the form of a report as follows. Various breast cancer imaging techniques were extracted as follows: mammography, contrast-enhanced mammography, digital tomosynthesis, sonography, sonoelastography, magnetic resonance imaging, magnetic elastography, diffusion-weighted imaging, magnetic spectroscopy, nuclear medicine, optical imaging, and microwave imaging. Conclusion: The choice of these methods depends on the patient's state and stage, the age of the individual and the density of the breast tissue. Hybrid imaging techniques appear to be an acceptable way to improve detection of breast cancer. This review article can be useful in choosing the right method for imaging in people suspected of breast cancer.

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“…Mammographically occult breast cancer is a well-known entity; recent studies have shown that MRI cannot be used as a single imaging modality for the evaluation of breast cancer, as false negative results can occur 1…”

Section: Descriptionmentioning

confidence: 99%

Mammographically and MRI occult breast cancer

2019

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DesCripTionWe are presenting the case of a 64-years-old woman who had normal bilateral mammogram 1 year prior to presenting with a palpable 30 mm left breast lump which was this time neither seen on mammogram (figure 1) or breast MRI (figure 2), only vaguely seen (under sized 20 mm) on breast ultrasound scan (figure 3).Postoperative histology revealed 37.5 mm invasive duct carcinoma grade II estrogen receptor, progesterone receptor positive, Her2 negative; sentinel lymph node biopsy was negative.Mammographically occult breast cancer is a wellknown entity; recent studies have shown that MRI cannot be used as a single imaging modality for the evaluation of breast cancer, as false negative results can occur. 1 Various histological subtypes of breast cancer have been described as sometimes presenting with non-enhancement or late enhancement on breast MRI. These include lobular, mucinous and tubular cancers. 2 We believe that this is the first case in literature who is both mammographically and MRI occult also with a very common histology which is not known to be occult on mammogram or MRI. RefeRences1 Maxwell AJ, Lim YY, Hurley E, et al. False-negative MRI breast screening in high-risk women. Clin Radiol 2017;72:207-16. 2 Kuhl CK, Schild HH. Dynamic image interpretation of MRI of the breast. J Magn Reson Imaging 2000;12:965-74.Figure 1 Cranio-caudal (CC) and medio-lateral-oblique (MLO) screening mammograms of 2017 (right) and 2018 (left) did not reveal any suspecious lesion, post guide wire mammograms: CC (right) and MLO (left). The barb of the wire is in close relation to the post-biopsy clip.Figure 2 Breast MRI: MRI maximum intensity projection image. Bilateral nodular breasts, but mass lesion in left breast cannot be appreciated.Figure 3 Left breast ultrasound scan: left breast medial aspect vague but visible hypoechoic 20 mm sized mass containing post-biopsy clip. Learning points► Breast cancer can be occult on both mammogram and MRI. ► We strongly believe that a breast ultrasound scan must be done for any patient presenting with breast lump who has a normal mammogram.on August 1, 2020 by guest. Protected by copyright.

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False-negative MRI breast screening in high-risk women

Cited by 17 publications

References 31 publications

Large Non-enhancing Breast Cancer on Breast Magnetic Resonance Imaging: A Case Report

Large Non-enhancing Breast Cancer on Breast Magnetic Resonance Imaging: A Case Report

A review of various modalities in breast imaging: technical aspects and clinical outcomes

Mammographically and MRI occult breast cancer

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