False Human Immunodeficiency Virus Test Results Associated with Rheumatoid Factors in Rheumatoid Arthritis

Li, Yun‐Chun; Yang, Fan Nils; Ji, Xiaoyan; Fang, Zhongjun; Liu, Jun; Wang, Yue

doi:10.1016/s1001-9294(14)60036-5

Cited by 12 publications

(7 citation statements)

References 9 publications

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“…In this study, the antibody titers reduced after 6 months of antiretroviral therapy and no patients developed RA at 1 year follow-up. Conversely, Li et al found false-positive HIV serology in 16 % of their cohort of Chinese RA patients [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Inflammatory arthritis in HIV positive patients: A practical guide

et al. 2016

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BackgroundMusculoskeletal manifestations of the human immunodeficiency virus (HIV) have been described since the outset of the global HIV epidemic. Articular syndromes that have been described in association with HIV include HIV-associated arthropathy, seronegative spondyloarthropathies (SPA) (reactive arthritis, psoriatic arthritis (PsA) and undifferentiated SPA), rheumatoid arthritis (RA) and painful articular syndrome.MethodsWe carried out a computer-assisted search of PubMed for the medical literature from January 1981 to January 2015 using the keywords HIV, acquired immune-deficiency syndrome, rheumatic manifestations, arthritis, spondyloarthropathy, anti-TNF and disease modifying antirheumatic drugs. Only English language literature was included and only studies involving adult human subjects were assessed.ResultsThere are challenges in the management of inflammatory arthritis in patients who are HIV-positive, including difficulties in the assessment of disease activity and limited information on the safety of immunosuppressive drugs in these individuals.ConclusionsThis review focuses on the clinical characteristics of the inflammatory articular syndromes that have been described in association with HIV infection and discusses the therapeutic options for these patients.

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Section: Resultsmentioning

confidence: 99%

Inflammatory arthritis in HIV positive patients: A practical guide

et al. 2016

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“…B. Autoantikörper, Immunkomplexe, andere Infektionen oder vorausgegangene Impfungen bzw. das Vorliegen von Rheumafaktoren sein [12]. c Anamnestischer oder klinischer Verdacht auf eine erst kürzlich erworbene Infektion (Expositionszeitpunkt < 6 Wochen).…”

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Nachweis einer Infektion mit Humanem Immundefizienzvirus (HIV): Serologisches Screening mit nachfolgender Bestätigungsdiagnostik durch Antikörper-basierte Testsysteme und/oder durch HIV-Nukleinsäure-Nachweis

2015

Bundesgesundheitsbl.

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“…Indeed, studies showed that SARS-CoV-2 stimulates a polyclonal autoreactive B-cell response [ 35 , 36 ]. In hospitalized COVID-19 patients, this included the induction of rheumatoid factor [ 37 ], a group of autoantibodies capable of cross-linking human and animal Abs and interfering with diagnostic assays including HIV screening tests [ 38 , 39 ]. Thus, SARS-CoV-2 infection in patient 1 might have induced a transient autoreactive B-cell response resulting in the production of Abs capable of cross-linking HIV diagnostic test components.…”

Section: Discussionmentioning

confidence: 99%

False-Positive Screening and Confirmatory HIV Diagnostic Test in a Patient with Cured SARS-CoV-2 Infection Is Not Mediated by Env/Spike Cross-Reactive Antibodies

Elsner,

Appeltrath,

Konik

et al. 2023

Viruses

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Acute SARS-CoV-2 infection has been associated with false-positive HIV screening tests. The underlying mechanism is unclear, and for clinical cases, evidence beyond a temporal connection is missing. However, several experimental studies point toward SARS-CoV-2 spike/HIV-1 envelope (Env) cross-reactive antibodies (Abs) as a cause. Here, we present the first case of an individual with convalescent SARS-CoV-2 infection testing false positive in both an HIV screening and confirmatory test. Longitudinal sampling showed that the phenomenon was temporary but lasted for at least 3 months before waning. After excluding a multitude of common determinants for assay interference, we further show by antibody depletion studies that SARS-CoV-2-spike-specific Abs did not cross-react with HIV-1 gp120 in the patient sample. No additional case of HIV test interference was identified in a cohort of 66 individuals who presented to a post-COVID-19 outpatient clinic. We conclude the SARS-CoV-2-associated HIV test interference to be a temporary process capable of disturbing both screening and confirmatory assays. The assay interference is short-lived and/or rare but should be considered by physicians as a possible explanation for unexpected HIV diagnostic results in patients with a recent SARS-CoV-2 infection.

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False Human Immunodeficiency Virus Test Results Associated with Rheumatoid Factors in Rheumatoid Arthritis

Abstract: Immunological factors, including RF and anti-CCP antibody, may influence the screening of HIV by ECLIA, producing false-positive result.

Cited by 12 publications

References 9 publications

Inflammatory arthritis in HIV positive patients: A practical guide

Inflammatory arthritis in HIV positive patients: A practical guide

Nachweis einer Infektion mit Humanem Immundefizienzvirus (HIV): Serologisches Screening mit nachfolgender Bestätigungsdiagnostik durch Antikörper-basierte Testsysteme und/oder durch HIV-Nukleinsäure-Nachweis

False-Positive Screening and Confirmatory HIV Diagnostic Test in a Patient with Cured SARS-CoV-2 Infection Is Not Mediated by Env/Spike Cross-Reactive Antibodies

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