Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-κB Signaling Pathway

Abstract

Fallopia japonica (Asian knotweed) is a medicinal herb traditionally used to treat inflammation, among other conditions. However, the effects of F. japonica root extract (FJE) on airway inflammation associated with combined allergic rhinitis and asthma (CARAS) and the related mechanisms have not been investigated. This study examined the effect of FJE against CARAS in an ovalbumin (OVA)-induced CARAS mouse model. Six-week-old male BALB/c mice were randomly segregated into six groups. Mice were sensitized intraperitoneally with OVA on days 1, 8, and 15, and administered saline, Dexamethasone (1.5 mg/kg), or FJE (50, 100, or 200 mg/kg) once a day for 16 days. Nasal symptoms, inflammatory cells, OVA-specific immunoglobulins, cytokine production, mast cell activation, and nasal histopathology were assessed. Administration of FJE down-regulated OVA-specific IgE and up-regulated OVA-specific IgG2a in serum. FJE reduced the production of T helper (Th) type 2 cytokines, and the Th1 cytokine levels were enhanced in nasal and bronchoalveolar lavage fluid. Moreover, FJE positively regulated allergic responses by reducing the accumulation of inflammatory cells, improving nasal and lung histopathological characteristics, and inhibiting inflammation-associated cytokines. FJE positively modulated the IL-33/TSLP/NF-B signaling pathway, which is involved in regulating inflammatory cells, immunoglobulin levels, and pro-inflammatory cytokines at the molecular level.

Alleviating effect of Nexrutine on mucosal inflammation in mice with ulcerative colitis: Involvement of the RELA suppression

“…Additionally, the present study primarily focuses on the ameliorating effects of Nexrutine against self‐inflammatory damage of colonic epithelial cells. Considering the observations that Nexrutine reduced T helper (Th) 1 cell cytokines (TNF‐α, IL‐1β and IL‐6) while elevating the Th2 cell cytokine (IL‐10) in mouse clone tissues, and the NF‐κB activation is closely correlated with lymphocytes and other inflammatory cells, 45 Nexrutine may exert anti‐inflammatory functions through other pathways. However, this issue was not further concerned in the present study and is interesting for additional investigations.…”

Effects of Thymus quinquecostatus Celakovski on Allergic Responses in OVA-Induced Allergic Rhinitis Mice

“…Anti-histamines, anti-leukotrienes, nasal or oral glucocorticoids, and decongestants are the commonly used therapeutic options to relieve of symptoms during AR [53]. However, they have only partially inhibiting effects as well as often side effects such as headache, nasal and throat irritation, nosebleeds, and dryness of eyes, mouth, and nasal [54]. Therefore, safer and more effective agents against AR need to be developed and should be supported by the patients or healthcare providers.…”

“…Herbal medicines are commonly considered less toxic and having fewer side effects compared to synthetic agents [55]. TQ is one of the herbal medicines and has been used in pharmaceutical industries in Asia including China, Korea, Japan, Taiwan, and eastern Russia [54,56]. Additionally, since it has been used as food to enhance the flavor of tea or spice, it is one of the reasons to support the safety of TQ [57].…”

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

“…The modulatory effect of quercetin on epithelium-derived cytokines was also observed in experimental models of allergic airway inflammation as quercetin significantly decreased IL-25, IL-33, and TSLP levels in BAL and expression of this cytokine in lung tissue [127]. Recently, Fallopia japonica (Asian knotweed), a traditional medicinal herb rich in polyphenols such as resveratrol and flavones, was reported to target the IL-33/TSLP signaling pathway, strongly reducing these cytokine levels in both nasal and bronchoalveolar lavage fluid in the allergic rhinitis and asthma mouse model [128].…”