Falling maternal age and incidence of down syndrome

Jones, D.C.; Lowry, R. Brian

doi:10.1016/s0140-6736(75)91671-2

Cited by 4 publications

(4 citation statements)

References 1 publication

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“…The fall in mean maternal age of mothers of children with Down syndrome is obvious in Japanese materials. The same trend has also been noted in Hokkaido, Japan (Shiono et al 1975), New Zealand (Gardner et al 1973), Sweden (Lindsjo 1974) and British Columbia (Jones & Lowry 1975, Lowry et al 1976).…”

Section: Dlscusslonsupporting

confidence: 66%

“…Jones & Lowry (1975) and Lowry et al (1976) observed an increasing trend, but could not clarify whether this was a true biologic increase or if it was due to better ascertainment. Tanaka (1969) reported the incidence of mongo1 births to be 0.111 % in the period 1962-66 in Iwate, Japan.…”

Section: Dlscusslonmentioning

confidence: 92%

“…The shift of child-birth to younger mothers in the general population has recently been observed in several countries, including Japan. Some authors (Penrose 1967, Collmann & Stoller 1969 have found a decreased incidence of Down syndrome, but others (Uchida 1970, Jones & Lowry 1975, Lowry et al 1976) have not found any such tendency.…”

mentioning

confidence: 97%

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Down syndrome and maternal age in Japan, 1950–1973

et al. 1977

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The mean maternal age and the percentage age distribution of 2,650 mothers of children with Down syndrome were calculated for 1950–1973, from hospital records. Mean maternal age has dropped both for controls (28.55→27.37) and Down syndrome (31.26→29.59). The observed maternal age distributions were very similar to those expected in corresponding periods, from the age specific incidences of Collmann & Stoller (1962). It is conceivable that the fall in maternal age in Down syndrome in recent years has resulted from the general trend to decreasing maternal age. There has been no change in the age‐specific incidences of Down syndrome. The incidence of Down syndrome seems to be falling in Japan.

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Section: Dlscusslonsupporting

confidence: 66%

Section: Dlscusslonmentioning

confidence: 92%

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Down syndrome and maternal age in Japan, 1950–1973

et al. 1977

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“…By contrast, Harlap (1974) found an unusually high incidence of 2-4 per Table 1. Studies of changes in the incidence of Down syndrome Author Collmann & Stoller (1969) Zeuten, Nielsen & Nielsen (1973) O 'Brien & Gill (1972) Jones & Lowry (1975) Uchida (1970) Mikkelsen et al (1976) Country Victoria, Australia Denmark Ireland Canada Canada Denmark Period studied 1942-57 1950-70 1966-71 1952-73 1960-68 1960-71 1000 births in Jerusalem. Even in one country the incidence may vary between different areas.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting the incidence of Down syndrome in Scotland

Holloway

Emery

1977

J. Biosoc. Sci.

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The incidence of Down syndrome in Scotland between 1960 and 1974 was estimated using data from thirteen Area Health Boards. Incidences in individual years, in different months of the year and in different maternal age groups were also determined. There was an apparent increase in incidence in more recent years almost certainly due to increased ascertainment. This may have obscured any decrease in incidence which might be expected as a result of a decrease in mean maternal age during this period and the introduction of antenatal diagnosis. No seasonal differences in incidence could be detected either in the whole area or in individual Area Health Boards. There was an increase in incidence with maternal age which was not significantly different from that found by other investigators. There was also an indication of an increase in relative incidence (% Down syndrome births/ % live births) over the period 1966-74 in mothers aged 35 years and older.

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The Prenatal Diagnosis of Chromosomal Disorders

Milunsky

1979

Genetic Disorders and the Fetus

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Falling maternal age and incidence of down syndrome

Cited by 4 publications

References 1 publication

Down syndrome and maternal age in Japan, 1950–1973

Down syndrome and maternal age in Japan, 1950–1973

Factors affecting the incidence of Down syndrome in Scotland

The Prenatal Diagnosis of Chromosomal Disorders

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