Falling Coronary Heart Disease Rates

Luepker, Russell V.

doi:10.1161/circulationaha.115.019862

Cited by 16 publications

(8 citation statements)

References 15 publications

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“…C'est ainsi qu'en santé dite somatique, la mortalité associée aux pathologies cardiovasculaires (Luepker, 2016) ou aux cancers a pu être considérablement améliorée (Centers for Disease Control and Prevention, CDC, 2004). L'institut américain de santé mentale (National Institute of Mental Health, NIMH) a pris acte de ces constats en relevant, notamment par la voix de son ancien directeur Thomas Insel, que l'ensemble de la stratégie d'identification et de prise en charge des troubles neuropsychiatriques nécessitait d'être changée (Insel, 2009).…”

Section: Discussion : Place Des Psychologues Dans Le Champ De La Sant...unclassified

Les psychologues dans le champ de la santé mentale : les perspectives en promotion de la santé mentale positive

Carré

Shankland

Flaudias³

et al. 2021

Pratiques Psychologiques

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Section: Discussion : Place Des Psychologues Dans Le Champ De La Sant...unclassified

Les psychologues dans le champ de la santé mentale : les perspectives en promotion de la santé mentale positive

Carré

Shankland

Flaudias³

et al. 2021

Pratiques Psychologiques

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“…However, CVD remains the leading cause of mortality and morbidity in the developed countries. [7][8][9] According to advances in biological and information sciences in decades, we might expect that more smart and effective strategies for prevention, diagnosis, and treatment could be delivered at both the individual and population levels. 2)3) However, there is a growing gap of unmet need between the development of biotechnology and clinical application in the global CV healthcare system.…”

Section: Why Precision Cardiovascular (Cv) Medicinementioning

confidence: 99%

Challenges and Future in Precision Cardiovascular Medicine

Baek

2019

Cardiovasc Prev Pharmacother

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Cardiovascular disease (CVD) still remains the global leading cause of mortality and also impose major burdens on morbidity, quality of life, and societal costs despite of the remarkable progress of cardiovascular (CV) treatment over the past 50 years. CVD therapy improves CV outcomes in less than half of patients. Precision medicine is an attractive and advancing strategy to enhance for disease prevention, diagnosis, and tailored treatment and allocate limited resources more wisely and effectively. We are now in the middle of fourth industrial revolution by a robust confluence of biotechnology, physical science and information technologies. This approach is in its premature so far, but has begun to yield useful information that moves from the conventional 'average response' approach to more specific and targeted approaches governed by individual variability. This review aims to how precision medicine, genomics, and epigenetics work together to create a new era of CV precision medicine.

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“…Тем не менее считается, что большая часть профилактического потенциала еще не реализована. Многим больным при наличии показаний не удаётся осуществить эффективную реваскуляризацию миокарда [6]. Усилиями исследователей последних десятилетий удалось создать концепцию доказательной медицины.…”

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Assessment of the effectiveness of treatment in patients after acute coronary syndrome

et al. 2020

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Aim. To assess the effectiveness of secondary drug prevention and surgical myocardial revascularization in patients with coronary artery disease (CAD) during long-term follow-up after acute coronary syndrome (ACS).Material and methods. The study involved 400 patients with ACS discharged from the hospital in 2012-2016. The diagnosis was verified according to the European Society of Cardiology (ESC) guidelines. There were no exclusion criteria. We analyzed the data of medical records (complaints, medical history, physical examination, laboratory and instrumental data). Repeated data collection was carried out by distance survey and during a face-to-face examination during 2018. According to the clinical course of CAD, all patients were divided into 2 groups. Group 1 consisted of 151 patients with complicated course of CAD, group 2 — 249 patients with stable CAD. We analyzed drug therapy recommended at hospital discharge and taken at the time of the repeated examination. The drug names and daily dosage used for the secondary prevention of CAD were recorded. Assessment of survival without cardiovascular complications was carried out according to the Kaplan-Mayer analysis.Results. Seven-year mortality was 22,5%. The total number of cardiovascular events was 37,7%. The main reason for the frequent complications was the insufficient secondary prevention of CAD after ACS. We found that the drugs and their dosage did not have a significant effect on survival. Statin use is associated with a paradoxical increase in the number of complications. The increased frequency of use and dosage of statins are a consequence of unfavorable course of CAD and do not have the proper preventive effect. For some groups of drugs, we observed irregular intake over the observation period. The low effectiveness of therapy is not only due to insufficient doses, but also in the frequent use of generic drugs. The significant effect of coronary angiography on the probability of cardiovascular complications compared with stenting is due to high proportion of coronary angiography use without revascularization.Conclusion. The combination of following factors of drug therapy can explain the low effectiveness of secondary CAD prevention: low dose (26,1±2,8 mg for atorvastatin), irregular intake and common use of generic drugs (97,6% for statins), present in different ratios. The contribution of surgical treatment to reducing cardiovascular complications is lower, the more significant residual coronary artery stenosis.

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Falling Coronary Heart Disease Rates

Cited by 16 publications

References 15 publications

Les psychologues dans le champ de la santé mentale : les perspectives en promotion de la santé mentale positive

Les psychologues dans le champ de la santé mentale : les perspectives en promotion de la santé mentale positive

Challenges and Future in Precision Cardiovascular Medicine

Assessment of the effectiveness of treatment in patients after acute coronary syndrome

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