Fall in Nocturnal Serum Melatonin During Prepuberty and Pubescence

Waldhauser, Franz; Frisch, H; Waldhauser, M.; Weiszenbacher, Gunther; Zeitlhuber, U; Wurtman, R. J.

doi:10.1016/s0140-6736(84)90412-4

Cited by 266 publications

(141 citation statements)

References 17 publications

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“…The mean value found for midnight melatonin in young adults in the present study is very similar to that reported by Waldhauser et al (1984). The values of the middle-aged subjects did not differ from those of young adults, suggesting that the functional activity of the pineal gland does not decrease significantly over this period.…”

Section: Discussionsupporting

confidence: 89%

“…The present study has investigated whether longer-term treatment with 1-adrenoceptor blockers is similarly associated with reduced plasma melatonin concentrations, since this could have consequences for patients and might yield clues to the functional importance of melatonin in man. A recent study of melatonin secretion in normal subjects has reported that midnight melatonin levels decline in the period from childhood to young adulthood (Waldhauser et al, 1984). In the present study, therefore, we have also investigated whether a further decline occurs in later middle age.…”

Section: Introduction Methodsmentioning

confidence: 86%

See 1 more Smart Citation

Treatment with beta‐adrenoceptor blockers reduces plasma melatonin concentration.

Cowen¹,

Bevan²,

Gosden³

et al. 1985

Brit J Clinical Pharma

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In treated hypertensive patients plasma melatonin levels were lower in subjects receiving beta‐adrenoceptor blockers than those treated with diuretics. Melatonin concentrations in middle‐aged and young control subjects were similar to each other and to those of the diuretic‐ treated patients. The results suggest that treatment with beta‐ adrenoceptor blockers causes a persistent reduction in plasma melatonin but it is unclear if this finding has clinical implications.

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Section: Discussionsupporting

confidence: 89%

Section: Introduction Methodsmentioning

confidence: 86%

Treatment with beta‐adrenoceptor blockers reduces plasma melatonin concentration.

Cowen¹,

Bevan²,

Gosden³

et al. 1985

Brit J Clinical Pharma

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“…In adults, levels of urinary aMT6s have been shown to have high reproducibility over long periods, 40 though it remains unclear whether a single measurement of melatonin in adolescents is an adequate representation of long-term levels. Some evidence suggests that melatonin levels decline throughout childhood and puberty, 34,41,42 though other evidence suggests that urinary aMT6s secretion may remain constant after the onset of puberty. 36 Griefahn et al 37 reported that despite huge between-subject variability, within-subject levels of urinary excretion of melatonin metabolite remained constant from ages 3 to 18.…”

Section: Discussionmentioning

confidence: 99%

The effects of sleep and light at night on melatonin in adolescents

Hersh¹,

Sisti²,

Richiutti³

et al. 2015

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OBJECTIVE: The circadian hormone melatonin has wide-reaching effects on human physiology. In adolescents, the impact of nighttime light exposure and other modifiable behavioral factors on melatonin levels is poorly understood. DESIGN: We cross-sectionally examined the influence of nighttime behaviors on melatonin levels in 100 adolescents (average age: 15.7; 55 female, 45 male), who completed a self-administered questionnaire and provided a first morning urine sample to assay for urinary 6-sulfatoxymelatonin (aMT6s) levels. We used mixed-effects regression models to test for differences in aMT6s levels by categories of covariates. RESULTS: Self-reported sleep duration, ambient light levels during sleep, and use of electronics after turning off lights did not significantly predict aMT6s levels. Compared to those who reported weekend bedtimes before 11pm, urinary aMT6s levels were significantly lower among participants reporting weekend bedtimes after midnight (52.5 vs. 38.0 ng/mg creatinine, Ptrend=0.007). Sleep interruption also appeared to be significantly associated with lower urinary aMT6s levels, but only if lights were turned on during sleep interruption (43.0 ng/mg creatinine for participants with sleep interruption but not turning lights on, vs. 24.6 ng/mg creatinine for participants reporting that they turned on the light when their sleep was interrupted Pdifference=0.032). CONCLUSIONS: Our study suggests that self-reported sleeprelated behaviors have little to no effect on adolescent circadian systems, though larger studies are needed to confirm our findings.

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“…Circulating melatonin levels decline with age [28,29]. Plasma levels of melatonin are higher at nighttime throughout the life span, although it is the absolute concentrations that decline with age [30,31]. It has been shown that when melatonin is given, it provides neuroprotection [32,33] and improved cognitive function [34].…”

Section: Discussionmentioning

confidence: 99%

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

Bloomer

2017

ACIM

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Background: We have previously reported improvements in selected biochemical measures of health, as well as self reported well-being in men and women using the dietary supplement known as CLOCK ® . In this follow up investigation, we evaluated CLOCK ® at two different dosages using a randomized, placebo controlled, cross-over design in men and women with self reported low energy, impaired sleep quality and impaired well-being.Methods: 30 subjects (14 men and 16 women) were randomly assigned in double blind manner to ingest a botanical agent (CLOCK ® , containing Rosmarinus officinalis and Hemerocallis fulva at either 1gram or 1.5grams daily) or a placebo for two week periods with a two week wash out period after each condition assignment. Blood samples were collected pre and post each two week period in an overnight fasted state and analyzed for acetylcholine (ACh), choline, Brain Derived Neurotrophic Factor (BDNF), IGF-1, irisin, melatonin and serotonin. Heart rate and blood pressure were measured, as were subjective measures of well-being. The Leeds Sleep Evaluation Questionnaire was used as a measure of sleep quality and related variables.Results: ACh (22%), choline (19%), BDNF (44%), irisin (23%) and melatonin (8%) all increased significantly from pre to post intervention following intake of CLOCK ® (with a greater increase noted with 1gram vs. 1.5grams) but not placebo. Heart rate and blood pressure were unaffected by treatment (p>0.05). Time effects were noted for all well-being measures (p<0.05), except for anxious, depressed and tense, with improvements noted in all variables from pre to post intervention. When considering both supplement dosages together, improvements of 25% (attentiveness), 21% (alertness), 37% (focus) and 34% (energetic) were observed, with slightly less improvement noted for placebo. Although, not significant, CLOCK ® reduced the feeling of grogginess (25%), lethargy (14%) and sluggishness (18%); whereas there were minimal changes with the placebo. No differences were noted between conditions or across time in measures of sleep or related variables (p>0.05).

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Fall in Nocturnal Serum Melatonin During Prepuberty and Pubescence

Cited by 266 publications

References 17 publications

Treatment with beta‐adrenoceptor blockers reduces plasma melatonin concentration.

Treatment with beta‐adrenoceptor blockers reduces plasma melatonin concentration.

The effects of sleep and light at night on melatonin in adolescents

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

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