Falciparum malaria associated changes in biochemical indices in children

Nsonwu-Anyanwu, Augusta Chinyere; Egbe, Edmund Richard; Osuoha, Uloma; Inyang-Etoh, PC; Offor, Sunday Jeremiah; Usoro, Chinyere Adanna Opara

doi:10.5455/jmas.253029

Cited by 3 publications

(4 citation statements)

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“…Impairment of hepatic function associated with severe malaria may be responsible for the hypoproteinemia reported in this study [23].…”

Section: Discussionmentioning

confidence: 63%

Evaluation of Total Protein in Malaria Parasitaemia

Ikpeama,

Okolonkwo,

Nyenke

et al. 2023

IJPR

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Malaria endemicity is most common in the tropical region, continuous transmission still occurs in about 85 countries and regions. The liver is very essential in overall body physiology and it plays a very important role in the life cycle of malaria and its function may be altered due to malaria parasitaemia. This cross sectional study was aimed at evaluating the level of total protein in malaria parasitaemia among children attending Braithwaite Memorial Specialist Hospital, Palmars, Omega Children Hospital, Early Breed Group of Schools, St Francis Nursery and Primary school and Staff Nursery and Primary school in Port Harcourt, Rivers state Nigeria. Of the 1000 subjects within 1-10 years, 694 subjects had malaria parasitaemia while 306 subjects had no malaria and thus made up the control group. Venipuncture technique was used to collect samples for estimation of malaria parasite density and total protein (TP) using biuret method. The results showed low (873.8±30.44), moderate (3248±109.31) and high malaria (24813.8±877.22) densities with TP values of 42.70±0.50g/l, 43.21±0.60g/l and 39.64±0.60g/l respectively. There was a significant difference (P-value<0.05) in total protein (TP) levels among various groups of malaria densities. This study has shown that the impact of malaria on the liver health vary depending on the level of the infestation.

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“…Impairment of hepatic function associated with severe malaria may be responsible for the hypoproteinemia reported in this study [23].…”

Section: Discussionmentioning

confidence: 63%

Evaluation of Total Protein in Malaria Parasitaemia

Ikpeama,

Okolonkwo,

Nyenke

et al. 2023

IJPR

View full text Add to dashboard Cite

show abstract

“…Malaria parasites in the circulation need glucose from the host in order to produce energy, mainly via aerobic glycolysis, for their survival 4 . A previous report showed that high parasitaemia is associated with high glucose requirements by malaria parasites, which can lead to clinical hypoglycaemia 21 . Antimalarial drugs, such as quinine and quinidine have an effect on glucose metabolism in malaria patients, causing a decrease in BS level 5 .…”

Section: Discussionmentioning

confidence: 99%

Exploring pancreatic pathology in Plasmodium falciparum malaria patients

Glaharn

Punsawad

Ward

et al. 2018

Sci Rep

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Hypoglycaemia is an important complication of Plasmodium falciparum malaria infection, which can be lethal if not treated. A decrease in blood sugar (BS) level has been correlated with disease severity, parasitaemia and the use of certain antimalarial drugs. This study explored the relationship between pancreatic pathology, including the expressions of insulin and glucagon in the islets of Langerhans, and the BS levels in P. falciparum malaria patients. Pancreatic tissues from malaria patients were divided into three groups, namely those with BS < 40 mg/dl, BS = 40–120 mg/dl, and BS > 120 mg/dl. In P. falciparum malaria, pancreatic tissues showed numerous parasitised red blood cells (PRBCs) in the capillaries, oedema, acinar necrosis and the presence of inflammatory cells. The islet size and the expression of insulin were significantly increased in P. falciparum malaria patients with hypoglycaemia. In addition, insulin expression was positively correlated with islet size and negatively correlated with BS levels. This pioneer study documents an increase in insulin expression and an increase in islet size in hypoglycaemic patients with P. falciparum malaria. This could contribute to the pathogenesis of hypoglycaemia and provides evidence for the potential need to effectively manage the hypoglycaemia seen in malaria infection.

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“…Changes in haematological indices (haemoglobin, white cell count, red cell count, mean cellular volume, reticulocyte count, and haemoglobin factor) have been associated with incidences of malaria 3 . Metabolic melee associated with electrolyte and fluid imbalance and changes in the biological functions of the liver are common complications of malaria and are dependent on the level of parasitemia 4 . Alterations in packed cell volume (PCV), random blood glucose (RBG), total bilirubin (TB), total proteins (TP), albumin, serum electrolytes sodium (Na + ), potassium (K + ), chloride (Cl − ), bicarbonate (HCO 3− ), calcium (Ca 2+ ), magnesium (Mg 2+ ) and anion gap (AG) have been reported in children with malaria 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Metabolic melee associated with electrolyte and fluid imbalance and changes in the biological functions of the liver are common complications of malaria and are dependent on the level of parasitemia 4 . Alterations in packed cell volume (PCV), random blood glucose (RBG), total bilirubin (TB), total proteins (TP), albumin, serum electrolytes sodium (Na + ), potassium (K + ), chloride (Cl − ), bicarbonate (HCO 3− ), calcium (Ca 2+ ), magnesium (Mg 2+ ) and anion gap (AG) have been reported in children with malaria 4 . Malaria infections have been established to cause alterations in the plasma biochemical indices 5 .…”

Section: Introductionmentioning

confidence: 99%

In vivo studies on the biochemical indices of Plasmodium berghei infected mice treated with Alstonia boonei leaf and root extracts

2020

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Background: A study on the biochemical indices of albino mice infected with Plasmodium berghei and treated with Alstonia boonei aqueous and ethanolic extracts was undertaken. Methods: 216 males mice were randomly assigned to six treatment groups each containing six mice for both aqueous and ethanolic extracts experiments. P. berghei NK-65 was inoculated into the mice intraperitoneally and establishment of infection confirmed. Administration of extracts of was done after phytochemical and acute toxicity tests at varying concentrations, for both suppressive and curative tests. Blood samples collected by ocular puncturing were examined for the biochemical indices; ALT, AST, ALP, creatinine and total protein using the standard procedures. Results: A. boonei extracts suppression of P. berghei in mice was comparable to the standard drug. Significantly higher (p<0.05) recovery of mice treated with A. boonei extracts was observed. The biochemical indices examined all had signif- icantly (p<0.05) increased concentration after 7 days post-infection, except for total protein concentration which had no significant increase or decrease due to A. boonei extracts administration. Conclusion: The antiplasmodial potentials of A. boonei leaf and root extracts were dosage and duration-dependent, and have demonstrated satisfactory normalization of altered biochemical indices due to malaria. Keywords: In vivo; anti-malaria; Alstonia boonei; biochemical; Plasmodium berghei; mice.

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Falciparum malaria associated changes in biochemical indices in children

Cited by 3 publications

References 0 publications

Evaluation of Total Protein in Malaria Parasitaemia

Evaluation of Total Protein in Malaria Parasitaemia

Exploring pancreatic pathology in Plasmodium falciparum malaria patients

In vivo studies on the biochemical indices of Plasmodium berghei infected mice treated with Alstonia boonei leaf and root extracts

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