Falcine and parasagittal chondrosarcomas

Safaee, Michael; Clark, Aaron J.; Tihan, Tarık; Parsa, Andrew T.; Bloch, Orin

doi:10.1016/j.jocn.2013.01.004

Cited by 11 publications

(8 citation statements)

References 37 publications

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“…The pathogenesis is believed to originate from remnants of embryonal cartilage, metaplasia of meningeal fibroblasts, or primitive multipotent mesenchymal cells within the meninges. Hence, this tumor may closely resemble a cartilage-containing meningioma [2,4].…”

Section: Discussionmentioning

confidence: 96%

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Primary Intracranial Mesenchymal Chondrosarcoma: A Case Report

Cho¹

2018

J Med Cases

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Mesenchymal chondrosarcoma is a rare malignancy characterized by a biphasic pattern of small undifferentiated round cells intermixed with island of well-differentiated cartilaginous matrix. Although this type of tumor exhibits widespread distribution in the body, intracranial mesenchymal chondrosarcoma is rare. Radical excision of intracranial mesenchymal chondrosarcoma is important for obtaining a positive prognosis but the effectiveness of chemotherapy and radiotherapy remains uncertain. An 18-year-old patient presented with generalized seizure with magnetic resonance imaging showing a large dura-attached solid mass in the frontal convexity, which was presumptively diagnosed as a meningioma. Gross total resection of tumor was achieved without postoperative deficit. The final histological diagnosis was extra-skeletal mesenchymal chondrosarcoma, grade I. There was no adjuvant treatment after surgery. Five years after surgery, the prognosis was good after gross total resection only; however, long-term follow-up is necessary in the future.

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Section: Discussionmentioning

confidence: 96%

“…These lesions arise from the synchondroses of the basilar skull bones, and also occur in association with the meninges along the falx cerebri, tentorium, and convexity [1,2]. Due to their rarity, there is no data regarding the specific prognosis of intracranial mesenchymal chondrosarcomas.…”

Section: Introductionmentioning

confidence: 99%

Primary Intracranial Mesenchymal Chondrosarcoma: A Case Report

Cho¹

2018

J Med Cases

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“…[ 8 9 ] Including present case, 33 parasagittal chondrosarcoma cases have been reported in the literature. [ 6 ] Myxoid type at a parasagittal location is very rare; only one case beside the current one was presented in the literature. [ 10 ] In that case, Salcman et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 3 4 5 ] Parasagittal location for these tumors is very rare. [ 6 ] We report a rare case of primary myxoid chondrosarcoma at falx cerebri and discuss it with the current literature.…”

Section: Introductionmentioning

confidence: 99%

Falcine myxoid chondrosarcoma: A rare aggressive case

et al. 2018

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Chondrosarcoma is the second most common primary malignancy of bone after osteosarcoma. Cranial primary chondrosarcomas mostly originate from the skull base cartilage formation zones. Parasagittal falcine origin is very rare for primary extra-skeletal intracranial chondrosarcomas. We report a rare case of primary myxoid chondrosarcoma at falx cerebri. The patient was a 35-year-old lady with right arm and leg weakness. Her brain magnetic resonance imaging depicted a left parasagittal mass lesion attached to the falx cerebri. En bloc resection via left frontal craniotomy was performed. Three more local recurrences occurred in 9 months’ time since the index surgery, which were all managed with re-surgeries and/or adjuvant stereotactic radiosurgeries. This is the second case of myxoid type parasagittal chondrosarcoma but with the most protracted disease course. Even though surgery remains the mainstay of treatment for parasagittal chondrosarcomas, adjuvant therapy might be necessary in aggressive ones.

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“…The treatment of intracranial chondrosarcoma is controversial; surgical resection remains the primary treatment of meningeal chondrosarcoma regardless of the grade [35]. Radiation therapy is currently reserved for mesenchymal-type chondrosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Squash Cytology of a Dural-Based High-Grade Chondrosarcoma May Mimic That of Glioblastoma in the Central Nervous System

Lee

Kim²,

Chung³

et al. 2015

Acta Cytologica

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Background: Intracranial chondrosarcoma is rare, and most cases occur in the skull base. Intradural chondrosarcoma is even rarer. Case: Here, we describe a case of dural chondrosarcoma with a radiation history for nasopharyngeal carcinoma and a radical prostatectomy for prostatic cancer 15 and 8 years earlier, respectively. A 67-year-old man presented with a 3-week memory disturbance and dysarthria. Computed tomography and magnetic resonance images of the brain revealed a dural-based mass in the left temporal area. Under the impression of a glioblastoma, a resection and an intraoperative squash cytology were done. A necrotic dirty background as well as bluish-to-pinkish myxoid stroma were characteristic; the nuclei of highly pleomorphic tumor cells were hyperchromatic to vesicular with an occasional ground-glass appearance. The cytoplasm was of an eosinophilic hyalinized condensed morphology with an occasional granular appearance. Histologically, the lobulated mass was composed of hypercellular lobules of well-differentiated chondrocytes intermixed with anaplastic pleomorphic cells and diagnosed as a conventional grade III chondrosarcoma. These cells were immunoreactive for D2-40, S-100 protein and vimentin. Brain invasion was also found. Conclusion: Albeit rare, dural-based chondrosarcomas should be considered in the differential diagnosis for meningeal tumors, especially in the case of previous radiation therapy.

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Falcine and parasagittal chondrosarcomas

Cited by 11 publications

References 37 publications

Primary Intracranial Mesenchymal Chondrosarcoma: A Case Report

Primary Intracranial Mesenchymal Chondrosarcoma: A Case Report

Falcine myxoid chondrosarcoma: A rare aggressive case

Squash Cytology of a Dural-Based High-Grade Chondrosarcoma May Mimic That of Glioblastoma in the Central Nervous System

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