Faktor Karakteristik Klinis Host dan Sosiodemografik yang Berpengaruh Terhadap Kejadian Dengue Shock Syndrome

Abstract

Background : Dengue Shock Syndrome (DSS) is DHF grades III and IV, which can result in disease severity and lead to the death. In 2016, the number of DHF/DSS cases in Semarang City was 2.200 cases (IR=124,50) with 293 cases DSS or 15,4% from DHF, and CFR DSS cases is 9,21%.Methods : An observational analytic was conducted with case-control study design. Study populations were patients with diagnosis of DSS or diagnosis of DHF that admitted inK.R.M.T Wongsonegoro Hospital Semarang City. The samples were 70 cases and 70controls by consecutive sampling. Data were analyzed by logistic regression.Results : Patients DHF with age ≤ 15 years OR=4,277 (95% CI=1,325-13,598), secondary infection OR=2,807 (95% CI=1,116-7,055), hepatomegaly OR=3,206 (95% CI=1,055-9,745) and thrombocytopenia (<50.000/µL) OR=11,301 (95% CI= 4,674-27,325) is a factors that influenced for incidence of dengue shock syndrome. Sex, nausea/vomiting,hemoconcentration, BMI, blood type, prolonged acces to health services, signs of spontaneous bleeding, abdominal pain, hypotension, acces to health services, knowledge and awareness of parents / suffers were not associated with DSS.Conclusion : Host clinical characteristic variables were evident influenced to DSS is age ≤ 15 years, secondary infection, hepatomegaly, and thrombocytopenia (<50.000/µL).

Intrinsic Factors of Mortality Due to DHF in 2018-2021

“…Various reinfections are associated with dengue/DSS outbreaks, where cases are severe. Generally occur in children (Prasetya et al, 2017). Other studies also assume that secondary infection shows DEN-3 is the dominant viral serotype causing severe cases.…”

“…Another study in line is by Prasetya et al (2017), who said a statistical test of a history of suffering from DHF p-value 0.033 in the incidence of DHF in the city of Bandung. One of the factors affecting DHF mortality is a patient with a DHF record (p-value of 0.05) (Anggraini & Mahmudah, 2021).…”