Schizophrenia is a group of psychotic reactions that affect different areas of an individual's functioning, including thinking, communicating, receiving, interpreting reality, feeling and showing emotions as well as brain disorders characterized by chaotic thoughts, thoughts, hallucinations, and strange behaviors. One of the negative symptoms in schizophrenia is low self-esteem. Low self-esteem is one of the maladative responses in the range of neurobiology responses. The process of low self-esteem in schizophrenic clients can be explained by analyzing predisposing stressors and predispositions that are biological, psychological, and socio-cultural in nature so as to produce a maladative response, namely low self-esteem behavior. The response to stressors in low self-esteem patients gives rise to responses cognitively, affectively, physiologically, behaviorally and socially. Roy's adaptation theory approach is used by the author because the application of interventions to this theory focuses on changing the stimulus experienced by the patient and not his patient, so that it is the nurse who improves the interaction between the human being and his environment, so that the patient can improve health, have the ability to adapt and create changes to his environment. The research method used was a case study using mental nursing care in Mr.M with rsj low self-esteem disorder. Prof. Dr. Muhammad Ildrem. The client's medical diagnosis is paranoid schizoprenia. Nursing diagnosis of auditory hallucinations, social isolation, and low self-esteem. The results of the analysis show that nursing interventions with implementation strategies can lower signs and symptoms in clients after being given nursing measures.