Faisabilité et sécurité du portage de nouveau-né bénéficiant d’une hypothermie thérapeutique contrôlée dans le cadre d’une encéphalopathie anoxo-ischémique néonatale

Gançarski, Lucas; Langlet-Muteau, Claire; Fourié, Gwenaelle; Mertes, Cmara; Rondel, Jennifer; Escande, B; Dillenseger, Laurence; Zores, Claire; Kuhn, Pierre

doi:10.1016/j.perped.2023.01.019

Cited by 1 publication

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“…Finally, we did not adjust for infants’ environment in hospital (presence of parents, management of nociceptive stimuli) or for hypoglycaemia at the first blood test. This could be a neuroprotective factor, especially in preterm infants, and may have impacted our results 34 35. The adjustment for hypoglycaemia was not interpretable because of too many missing data on this variable.…”

Section: Discussionmentioning

confidence: 99%

Effect of gestational age on cerebral lesions in neonatal encephalopathy

Binet,

Debillon,

Beck

et al. 2024

Arch Dis Child Fetal Neonatal Ed

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ObjectiveTo determine the risk on brain lesions according to gestational age (GA) in neonates with neonatal encephalopathy.DesignSecondary analysis of the prospective national French population-based cohort, Long-Term Outcome of NeonataL EncePhALopathy.SettingFrench neonatal intensive care units.PatientsNeonates with moderate or severe neonatal encephalopathy (NE) born at ≥34 weeks’ GA (wGA) between September 2015 and March 2017.Main outcome measuresThe results of MRI performed within the first 12 days were classified in seven injured brain regions: basal ganglia and thalami, white matter (WM), cortex, posterior limb internal capsule, corpus callosum, brainstem and cerebellum. A given infant could have several brain structures affected. Risk of brain lesion according to GA was estimated by crude and adjusted ORs (aOR).ResultsMRI was available for 626 (78.8%) of the 794 included infants with NE. WM lesions predominated in preterm compared with term infants. Compared with 39–40 wGA neonates, those born at 34–35 wGA and 37–38 wGA had greater risk of WM lesions after adjusting for perinatal factors (aOR 4.0, 95% CI (1.5 to 10.7) and ORa 2.0, 95% CI (1.1 to 3.5), respectively).ConclusionWM is the main brain structure affected in late-preterm and early-term infants with NE, with fewer WM lesions as GA increases. This finding could help clinicians to estimate prognosis and improve the understanding of the pathophysiology of NE.Trial registration numberNCT02676063, ClinicalTrials.gov.

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Section: Discussionmentioning

confidence: 99%