Fair-split distribution of multi-dose vaccines with prioritized age groups and dynamic demand: The case study of COVID-19

Vahdani, Behnam; Mohammadi, Mehrdad; Thevenin, Simon; Gendreau, Michel; Dolgui, Alexandre; Meyer, Patrick

doi:10.1016/j.ejor.2023.03.032

Cited by 11 publications

(2 citation statements)

References 90 publications

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“…There is a vast body of work that was developed to compare COVID-19 vaccination strategies. Most of the previous research has been devoted to analyze within-country or within-region vaccine allocation [ 17 – 19 , 21 , 23 , 24 , 26 , 31 , 33 , 74 – 84 ], some has explored the optimal use of COVID-19 vaccines globally to reduce between- [ 20 , 22 , 85 , 86 ], or within-country inequities [ 84 , 87 , 88 ]. Covid19Vaxplorer adds to previous work with the hope of providing those countries or regions with limited modeling capabilities with a tool for vaccine allocation comparison.…”

Section: Discussionmentioning

confidence: 99%

Covid19Vaxplorer: A free, online, user-friendly COVID-19 vaccine allocation comparison tool

Trejo,

Hung,

Matrajt

2024

PLOS Glob Public Health

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There are many COVID-19 vaccines currently available, however, Low- and middle-income countries (LMIC) still have large proportions of their populations unvaccinated. Decision-makers must decide how to effectively allocate available vaccines (e.g. boosters or primary series vaccination, which age groups to target) but LMIC often lack the resources to undergo quantitative analyses of vaccine allocation, resulting in ad-hoc policies. We developed Covid19Vaxplorer (https://covid19vaxplorer.fredhutch.org/), a free, user-friendly online tool that simulates region-specific COVID-19 epidemics in conjunction with vaccination with the purpose of providing public health officials worldwide with a tool for vaccine allocation planning and comparison. We developed an age-structured mathematical model of SARS-CoV-2 transmission and COVID-19 vaccination. The model considers vaccination with up to three different vaccine products, primary series and boosters. We simulated partial immunity derived from waning of natural infection and vaccination. The model is embedded in an online tool, Covid19Vaxplorer that was optimized for its ease of use. By prompting users to fill information through several windows to input local parameters (e.g. cumulative and current prevalence), epidemiological parameters (e.g basic reproduction number, current social distancing interventions), vaccine parameters (e.g. vaccine efficacy, duration of immunity) and vaccine allocation (both by age groups and by vaccination status). Covid19Vaxplorer connects the user to the mathematical model and simulates, in real time, region-specific epidemics. The tool then produces key outcomes including expected numbers of deaths, hospitalizations and cases, with the possibility of simulating several scenarios of vaccine allocation at once for a side-by-side comparison. We provide two usage examples of Covid19Vaxplorer for vaccine allocation in Haiti and Afghanistan, which had as of Spring 2023, 2% and 33% of their populations vaccinated, and show that for these particular examples, using available vaccine as primary series vaccinations prevents more deaths than using them as boosters.

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Section: Discussionmentioning

confidence: 99%

Covid19Vaxplorer: A free, online, user-friendly COVID-19 vaccine allocation comparison tool

Trejo,

Hung,

Matrajt

2024

PLOS Glob Public Health

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“…They were also aware that such an action plan necessitates re-planing medical products’ production system and re-allocating/sharing limited health resources among different centers/regions to combat the pandemic as supply chain viability measures [7] , [8] , [9] , [10] , [11] , [12] . The success of such an action plan highly depends on two main problems: a precise enough estimation of the demand for medical products; and an efficient logistics network to produce, stock, distribute, and share such products [13] , [14] , [15] , [16] .…”

Section: Introductionmentioning

confidence: 99%

Production-sharing of critical resources with dynamic demand under pandemic situation: The COVID-19 pandemic

Vahdani

Mohammadi

Thevenin

et al. 2023

Omega

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Optimal multimodal multi-echelon vaccine distribution network design for low and medium-income countries with manufacturing infrastructure during healthcare emergencies

Kar,

Jenamani

2024

International Journal of Production Economics

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Fair-split distribution of multi-dose vaccines with prioritized age groups and dynamic demand: The case study of COVID-19

Cited by 11 publications

References 90 publications

Covid19Vaxplorer: A free, online, user-friendly COVID-19 vaccine allocation comparison tool

Covid19Vaxplorer: A free, online, user-friendly COVID-19 vaccine allocation comparison tool

Production-sharing of critical resources with dynamic demand under pandemic situation: The COVID-19 pandemic

Optimal multimodal multi-echelon vaccine distribution network design for low and medium-income countries with manufacturing infrastructure during healthcare emergencies

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