2007
DOI: 10.1523/jneurosci.2063-07.2007
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Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression

Abstract: Although depressed mood is a normal occurrence in response to adversity in all individuals, what distinguishes those who are vulnerable to major depressive disorder (MDD) is their inability to effectively regulate negative mood when it arises. Investigating the neural underpinnings of adaptive emotion regulation and the extent to which such processes are compromised in MDD may be helpful in understanding the pathophysiology of depression. We report results from a functional magnetic resonance imaging study dem… Show more

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Cited by 902 publications
(901 citation statements)
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“…In the context of emotion regulation, the amygdala was found to be a major recipient of activation associated with intended cognitive control of emotions mediated by medial prefrontal cortex areas leading to attenuation of amygdala activity (Herwig et al, 2007a;Johnstone et al, 2007;Phan et al, 2005). This is thought to result in reduced amygdala output towards midbrain and brainstem areas and accordingly in less physiological, for instance sympathetic activation (Bishop, 2009;Ochsner and Gross, 2005;Quirk et al, 2003).…”
Section: Emotion Regulationmentioning
confidence: 99%
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“…In the context of emotion regulation, the amygdala was found to be a major recipient of activation associated with intended cognitive control of emotions mediated by medial prefrontal cortex areas leading to attenuation of amygdala activity (Herwig et al, 2007a;Johnstone et al, 2007;Phan et al, 2005). This is thought to result in reduced amygdala output towards midbrain and brainstem areas and accordingly in less physiological, for instance sympathetic activation (Bishop, 2009;Ochsner and Gross, 2005;Quirk et al, 2003).…”
Section: Emotion Regulationmentioning
confidence: 99%
“…This is thought to result in reduced amygdala output towards midbrain and brainstem areas and accordingly in less physiological, for instance sympathetic activation (Bishop, 2009;Ochsner and Gross, 2005;Quirk et al, 2003). Disturbed emotion processing in the amygdala is also considered to be a pathophysiological feature of depression and anxiety (Bishop, 2009;DeRubeis et al, 2008), with implications of an impaired top-down control of amygdala activity (Johnstone et al, 2007).…”
Section: Emotion Regulationmentioning
confidence: 99%
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“…[21][22][23][24] . In contrast, both the size and the activity of the amygdala, a structure critical for fear-associated memories, are increased in depressed patients [25][26][27][28] .Consistent with brain imaging studies, depressed patients exhibit deficits in hippocampus-dependent memory tasks and are more sensitive to stressful events [24,29,30] . Changes in neurotransmitter levels, receptors, and serotonin reuptake transporters have also been found in depressed patients, such as increased glutamate, decreased serotonin 1A receptors and impaired serotonergic neurotransmission [31][32][33][34][35] .…”
mentioning
confidence: 61%