Failure to obtain functional equivalence between dopamine receptor blockade and extinction: Evidence supporting a sensory-motor conditioning hypothesis

Tombaugh, Tom N.; Szostak, Carolyn; Voorneveld, Peggy; Tombaugh, Jo W.

doi:10.1016/0091-3057(82)90015-6

Cited by 36 publications

(9 citation statements)

References 16 publications

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“…With regard to the issue of Hal's presumptive anhedonic or incentive-motivational effects on rodents (Fouriezos & Wise, 1976;Wise, 1982;Wise, Spindler, deWitt, & Gerber, 1978), the current data suggest that "motor" effects are detectable at the very same low doses that are presumed to produce anhedonia. Although the across-day decline in behavioral output that accompanies repetitive dosing with Hal has been attributed to the rat's loss of ability to experience the reinforcer in its full potency, the present data do not support this idea and favor a sensorimotor conditioning hypothesis (Tombaugh, Szostak, Voorneveld, & Tombaugh, 1982). From Figure 3 it is clear that time-on-task declines across sessions, especially in the 0.08 and 0.16 mg/kg groups; however, the Hal-induced increased tremor in the 10.0-25.0-Hz band occurred near its maximum extent (see Figure 5) on the very 1 st day of dosing (recall that the two-way ANOVA did not substantiate a day effect for power in the 10.0-25.0-Hz band).…”

Section: Discussioncontrasting

confidence: 96%

A new rodent model for neuroleptic-induced pseudo-Parkinsonism: Low doses of haloperidol increase forelimb tremor in the rat.

Fowler¹,

Liao²,

Skjoldager³

1990

Behavioral Neuroscience

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Rats were trained to use the right forelimb to exert continuous downward pressure on a force transducer and simultaneously to drink sweetened milk from a dipper controlled by the emitted force. Oscillations in forelimb force during this performance were spectrally analyzed to describe the tremorogenic effects of haloperidol (0.04, 0.08, or 0.16 mg/kg). Haloperidol reduced time-on-task and increased the variance of force oscillations in the 10.0-25.0-Hz frequency band. When atropine sulfate (5 mg/kg) was given along with haloperidol, time-on-task was partially restored, and the effects of haloperidol on the 10.0-25.0-Hz band were diminished. These data suggest that the behavioral deficits produced by relatively low doses of haloperidol in rats are analogous (and possibly homologous) to neuroleptic-induced Parkinsonian symptoms in humans.

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Section: Discussioncontrasting

confidence: 96%

A new rodent model for neuroleptic-induced pseudo-Parkinsonism: Low doses of haloperidol increase forelimb tremor in the rat.

Fowler¹,

Liao²,

Skjoldager³

1990

Behavioral Neuroscience

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“…Several lines of study confirm that they do so by blunting reward function itself (Wise 1982(Wise , 2004aBeninger 1983;Smith 1995) rather than, as has been suggested (Mason et al 1980;Koob 1982;Tombaugh et al 1982;Salamone 1986), by simply impairing performance capacity.…”

Section: Importance Of Dopamine For Non-food Reinforcementmentioning

confidence: 72%

“…Dopamine antagonists impair learning (Wise & Schwartz 1981) and, by extinguishing them, previously learned (Wise et al 1978a,b) instrumental responding for food. Several lines of study confirm that they do so by blunting reward function itself (Wise 1982(Wise , 2004aBeninger 1983;Smith 1995) rather than, as has been suggested (Mason et al 1980;Koob 1982;Tombaugh et al 1982;Salamone 1986), by simply impairing performance capacity.…”

Section: Importance Of Dopamine For Non-food Reinforcementmentioning

confidence: 93%

Role of brain dopamine in food reward and reinforcement

Wise

2006

Phil. Trans. R. Soc. B

374

274

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The ability of food to establish and maintain response habits and conditioned preferences depends largely on the function of brain dopamine systems. While dopaminergic transmission in the nucleus accumbens appears sufficient for some forms of reward, the role of dopamine in food reward does not appear to be restricted to this region. Dopamine plays an important role in both the ability to energize feeding and to reinforce food-seeking behaviour; the role in energizing feeding is secondary to the prerequisite role in reinforcement. Dopaminergic activation is triggered by the auditory and visual as well as the tactile, olfactory, and gustatory stimuli of foods. While dopamine plays a central role in the feeding and food-seeking of normal animals, some food rewarded learning can be seen in genetically engineered dopamine-deficient mice.

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“…Others have suggested that a similar problem confounds nondevelopmental reward studies (Ettenberg, Koob, & Bloom, 1981;Tombaugh, Szostak, Voorneveld, & Tombaugh, 1982), although Wise (1982) contends that the DA reward (anhedonia) theory is accurate as long as dose and time-course problems are minimized (see also Heyman, Kinzie, & Seiden, 1986). In general, however, results of Experiments 6 and 7 are not inconsistent with the anhedonia theory, as long as the DA D-1 receptor is presumed to be critical for reward.…”

Section: Discussionmentioning

confidence: 99%

Dopamine D‐2 receptor mediation of response suppression learning of young rats

McDougall

Nonneman

1989

Developmental Psychobiology

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In three experiments, the effects of augmenting or blocking dopamine (DA) D-2 receptor activity on the ontogeny of response suppression learning of preweanling rat pups were determined. In the initial experiment, rat pups were trained to traverse a straight alley for nipple attachment to an anesthetized dam. When footshock (0.2 mA, 0.5 sec) was made contingent on responding, younger (11- and 13-day-olds) rat pups were deficient to older (17- and 19-day-olds) pups at withholding punished responding. In the subsequent experiments, response suppression learning was assessed after injecting 11- and 17-day-old rat pups with the specific DA D-2 agonist, LY 171555 (0.005-, 0.01-, and 0.1-mg/kg, i.p.), or the specific DA D-2 antagonist, sulpiride (5.0-, 15.0-, and 50.0-mg/kg, i.p.). LY 171555 enhanced the punished responding of both the 11- and 17-day-old rat pups; whereas, sulpiride increased the punished responding of the 17-, but not the 11-day-olds. In four additional experiments, the effects of LY 171555 and sulpiride on the locomotor activity, nociception, and reinforcement processes of 17-day-old rat pups was assessed. Rat pups given LY 171555 (0.01 mg/kg, i.p.) exhibited enhanced locomotor activity and a trend towards hyperanalgesia using a hot plate task. Sulpiride (15.0 mg/kg, i.p.) completely antagonized LY 171555's activity enhancing effects and had hyperalgesic properties. In two experiments, sulpiride did not affect the nonpunished appetitive responding of the 17-day-olds; whereas, haloperidol-treated pups responded on fewer reinforced trials than did saline-treated pups. Therefore, these results indicate that the response suppression learning of 17-day-old rat pups is mediated, at least partially, by a DAD-2 receptor system, and that D-2 receptors are also involved in the locomotor activity and nociceptive responses of young rat pups.

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Failure to obtain functional equivalence between dopamine receptor blockade and extinction: Evidence supporting a sensory-motor conditioning hypothesis

Cited by 36 publications

References 16 publications

A new rodent model for neuroleptic-induced pseudo-Parkinsonism: Low doses of haloperidol increase forelimb tremor in the rat.

A new rodent model for neuroleptic-induced pseudo-Parkinsonism: Low doses of haloperidol increase forelimb tremor in the rat.

Role of brain dopamine in food reward and reinforcement

Dopamine D‐2 receptor mediation of response suppression learning of young rats

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