Failure to gulp surface air induces swim bladder adenomas in Japanese medaka            (&lt;i&gt;Oryzias latipes&lt;/i&gt;)

Furukawa, Satoshi; MACHIDA, Yuichiro; Takeuchi, Kazuhiko; Hoshikawa, Yumiko; Irie, Kota

doi:10.1293/tox.2022-0030

Cited by 3 publications

(3 citation statements)

References 41 publications

(66 reference statements)

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“…The intake of exogenous air from the surface is a common feature for intitial swim bladder inflation in many species of fish [40][41][42][43][44]. However, few studies have considered what sensory information is required to achieve neutral buoyancy.…”

Section: Discussionmentioning

confidence: 99%

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A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line

Venuto

Thibodeau-Beganny

Trapani

et al. 2023

Preprint

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Larval zebrafish achieve neutral buoyancy between 4-5 days post-fertilization by swimming up to the surface and taking in air through their mouths to inflate their swim bladders. We define this behavior as 'surfacing'. Little is known about the sensory basis for this underappreciated behavior of larval fish. A strong candidate is the mechanosensory lateral line, a hair cell-based sensory system that detects hydrodynamic information from sources like water currents, predators, prey, and surface waves. However, a role for the lateral line in mediating initial inflation of the swim bladder has not been reported. To explore the connection between the lateral line and surfacing, we utilized a genetic mutant (lhfpl5b-/-) that renders the zebrafish lateral line insensitive to mechanical stimuli. We observe that approximately half of these lateral line mutants over-inflate their swim bladders during initial inflation and become positively buoyant. Thus, we hypothesize that larval zebrafish use their lateral line to moderate interactions with the air-water interface during surfacing to regulate swim bladder inflation. To test the hypothesis that lateral line defects are responsible for swim bladder over-inflation, we show exogenous air is required for the hyperinflation phenotype and transgenic rescue of hair cell function restores normal inflation. We also find that chemical ablation of anterior lateral line hair cells in wild type larvae causes hyperinflation. Furthermore, we show that manipulation of lateral line sensory information results in abnormal inflation. Finally, we report spatial and temporal differences in the surfacing behavior between wild type and lateral line mutant larvae. In summary, we propose a novel sensory basis for achieving neutral buoyancy where larval zebrafish use their lateral line to sense the air-water interface and regulate initial swim bladder inflation.

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Section: Discussionmentioning

confidence: 99%

“…The intake of exogenous air from the surface is a common feature for intitial swim bladder inflation in many species of fish (Furukawa et al, 2022; Goolish and Okutake, 1999; Jones and Marshall, 1953; Korsøen et al, 2012; v. Ledebur and Wunder, 1937).…”

Section: Discussionmentioning

confidence: 99%

A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line

Venuto

Thibodeau-Beganny

Trapani

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The intake of exogenous air from the surface is a common feature for intitial swim bladder inflation in many species of fish ( Furukawa et al, 2022 ; Goolish and Okutake, 1999 ; Jones and Marshall, 1953 ; Korsøen et al, 2012 ; von Ledebur and Wunder, 1937 ). However, few studies have considered what sensory information is required to achieve neutral buoyancy.…”

Section: Discussionmentioning

confidence: 99%

A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line

Venuto

Thibodeau-Beganny

Trapani

et al. 2023

Journal of Experimental Biology

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Larval zebrafish achieve neutral buoyancy by swimming up to the surface and taking in air through their mouths to inflate their swim bladders. We define this behavior as ‘surfacing’. Little is known about the sensory basis for this underappreciated behavior of larval fish. A strong candidate is the mechanosensory lateral line, a hair cell-based sensory system that detects hydrodynamic information from sources like water currents, predators, prey, and surface waves. However, a role for the lateral line in mediating initial inflation of the swim bladder has not been reported. To explore the connection between the lateral line and surfacing, we utilized a genetic mutant (lhfpl5b−/-) that renders the zebrafish lateral line insensitive to mechanical stimuli. We observe that approximately half of these lateral line mutants over-inflate their swim bladders during initial inflation and become positively buoyant. Thus, we hypothesize that larval zebrafish use their lateral line to moderate interactions with the air-water interface during surfacing to regulate swim bladder inflation. To test the hypothesis that lateral line defects are responsible for swim bladder over-inflation, we show exogenous air is required for the hyperinflation phenotype and transgenic rescue of hair cell function restores normal inflation. We also find that chemical ablation of anterior lateral line hair cells in wild type larvae causes hyperinflation. Furthermore, we show that manipulation of lateral line sensory information results in abnormal inflation. Finally, we report spatial and temporal differences in the surfacing behavior between wild type and lateral line mutant larvae. In summary, we propose a novel sensory basis for achieving neutral buoyancy where larval zebrafish use their lateral line to sense the air-water interface and regulate initial swim bladder inflation.

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Comparative developmental toxicities of zebrafish towards structurally diverse per- and polyfluoroalkyl substances

Gui,

Guo,

Wang

et al. 2023

Science of The Total Environment

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Failure to gulp surface air induces swim bladder adenomas in Japanese medaka (<i>Oryzias latipes</i>)

Cited by 3 publications

References 41 publications

A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line

A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line

A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line

Comparative developmental toxicities of zebrafish towards structurally diverse per- and polyfluoroalkyl substances

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