Failure to detect vertical transmission of hepatitis C virus

Reinus, John F.; Leikin, Enid; Hj, Alter; Cheung, Ling; Shindo, Michiko; Jett, Betsy W.; Piazza, S.; Shih, J.W.-K.

doi:10.1016/0020-7292(93)90486-g

Cited by 15 publications

(15 citation statements)

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“…These facts suggest that intraspousal transmission was not the main route of infection. Several studies report the transmission of H C V from mother t o child (13)(14)(15)(16), although the incidence is low (15,16). No significant difference in prevalence of anti-HCV was observed in the offspring of the anti-HCV positive mothers vs the other age-matched study participants.…”

Section: Scand J Infect Dis 29mentioning

confidence: 77%

Routes of Transimission of Hepatitis C Virus in an Endemic Rural Area of Japan : Molecular Epidemiologic Study of Hepatitis C Virus Infection

Noguchi

Sata

Suzuki

et al. 1997

Scandinavian Journal of Infectious Diseases

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We conducted an epidemiological study to investigate the routes of transmission of hepatitis C virus (HCV) infection in an area endemic for HCV. Subjects were the 857 adult inhabitants of K area, Japan. The prevalence of antibody to HCV (anti-HCV) was 26.3%. The HCV genotype 1b was the most prevalent (89.3%) among the anti-HCV positive subjects. Molecular evolutionary analysis, based on the nucleotide sequences of the HCV core region from 23 participants with type 1b, showed that the isolates were distributed into more than 1 group. Multivariate regression analysis demonstrated that an age over 40 years, a history of blood transfusion, the presence of antibody to hepatitis B core antigen (anti-HBc), or a history of surgery were each independently associated with the presence of anti-HCV. No significant differences in the presence of anti-HCV prevalence were observed between the wives of men positive for anti-HCV (33.3%) and age-matched women (36.4%), or between the husbands of women positive for anti-HCV (36.4%) and age-matched men (38.3%), from the same area. Findings suggest that the various strains of HCV type 1b were transmitted via medical procedures, not by the intrafamilial route.

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Section: Scand J Infect Dis 29mentioning

confidence: 77%

Routes of Transimission of Hepatitis C Virus in an Endemic Rural Area of Japan : Molecular Epidemiologic Study of Hepatitis C Virus Infection

Noguchi

Sata

Suzuki

et al. 1997

Scandinavian Journal of Infectious Diseases

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“…A total of 29 articles published between 1992 and 1996 fulfilled the above criteria; 21 of these studies examined vertical hepatitis C transmission 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 with the remainder examining hepatitis C transmission after bone marrow or solid organ transplantation (n=3),32 33 34 transfusion of blood components (n=3),35 36 37 and needlestick exposure (n=2) 38 39…”

Section: Resultsmentioning

confidence: 99%

Systematic review of role of polymerase chain reaction in defining infectiousness among people infected with hepatitis C virus

Dore

Kaldor

McCaughan

1997

BMJ

109

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Objective: To assess the role of polymerase chain reaction in defining infectiousness among people infected with hepatitis C virus. Design: Published studies of hepatitis C transmission were examined. Twenty nine studies with identified sources of hepatitis C infection who were tested for presence of hepatitis C RNA by polymerase chain reaction were reviewed, including studies of vertical transmission (n = 21), transmission after transplantation (n = 3), transfusion of blood components (n = 3), and needlestick exposure (n = 2). Subjects: All patients identified in studies. Results: A total of 2022 people who had been exposed to sources positive for antibody to hepatitis C were identified. Among 1148 people exposed to sources positive by polymerase chain reaction 148 cases of transmission occurred compared with no definite case among 874 people exposed to negative sources. Rates of transmission from positive sources were 6.2% for perinatal exposure, 6.1% after needlestick exposure, 78% after solid organ or bone marrow transplantation, and 83% after transfusion of blood components. Other factors influencing risk of vertical transmission were coinfection with HIV and level of hepatitis C viraemia. Conclusions: Negative results by polymerase chain reaction indicate an extremely low probability of transmission of hepatitis C from a person with antibody to hepatitis C.

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“…Mother-to-child transmission of HCV has been documented repeatedly. The overall risk of perinatal vertical transmission varies considerably in different investigations of various geographic regions, and has been estimated to be approximately 7 percent, ranging from 0 to 18 percent (8,9). It is likely that vertical transmission occurs only in HCV RNA-positive mothers (10).…”

Section: Abbreviationsmentioning

confidence: 99%

Obstetric risks and vertical transmission of hepatitis C virus infection in pregnancy

Hillemanns¹,

DANNECKER²,

KIMMIG³

et al. 2000

Acta Obstet Gynecol Scand

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Failure to detect vertical transmission of hepatitis C virus

Cited by 15 publications

References 0 publications

Routes of Transimission of Hepatitis C Virus in an Endemic Rural Area of Japan : Molecular Epidemiologic Study of Hepatitis C Virus Infection

Routes of Transimission of Hepatitis C Virus in an Endemic Rural Area of Japan : Molecular Epidemiologic Study of Hepatitis C Virus Infection

Systematic review of role of polymerase chain reaction in defining infectiousness among people infected with hepatitis C virus

Obstetric risks and vertical transmission of hepatitis C virus infection in pregnancy

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