Failure to Demonstrate Immunoglobulin E in Glomeruli of Patients With Various Nephropathies

Abstract

An immunofluorescence study of 119 kidney biopsies from a variety of renal affections, including transplants, is presented. The investigation was carried out with special reference to the possible presence of IgE, but simultaneously, other immunoglobulin classes (IgG, IgA, IgM) as well as complement (C 3) and fibronogen were sought for. Out of the 119 biopsies examined, 117 were negative if tested with a monospecific anti‐IgE conjugate. The only definitely positive finding of IgE came from two patients with amyloidosis.