Failure of the dual orexin receptor antagonist suvorexant to engender drug discrimination in rats
Michel A Steiner,
Michael Toeroek-Schafroth,
Lisa Dacome
et al.
Abstract:For abuse potential assessment, U.S. Food and Drug Administration (FDA) requests that new, brain-penetrating drugs are ideally compared with approved drugs that share the mechanism of action and are judged to have abuse liability by the Drug Enforcement Agency. For development of the dual orexin receptor antagonist (DORA) daridorexant, the FDA recommended conducting a rat drug discrimination paradigm against the approved, schedule IV, DORA suvorexant. Surprisingly, at suvorexant plasma levels up to three-fold … Show more
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