Failure of Systemic Analgesic Agents to Alter the Absolute Sensory Threshold for the Simple Detection of Pain

Analgesic Effects of Alcohol: A Systematic Review and Meta-Analysis of Controlled Experimental Studies in Healthy Participants

“…Metaanalysis was accordingly rerun including laboratory as a second-order random factor 43 , with a common coding given to comparisons obtained from the same laboratory. In line with the fairly wide distribution of effects sizes from the same laboratories illustrated in Figure 3 Chapman et al 8 , g=0.38, which reported semi-IQRs rather than SDs. ALCOHOL AND PAIN 18 studies.…”

Tegaserod, a 5‐HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects

“…In this respect, the analysis of the responses to supra‐threshold stimuli appears to be more sensitive for the demonstration of analgesic properties 34 ,. 35 Recordings of the RIII reflex, which reflects the spinal transmission of nociceptive signals, have been widely used to analyse the mechanisms of action of various analgesics in healthy subjects 36 ,. 37 Analysis of the effects of visceral stimuli on the RIII reflex might in fact be more sensitive than simple psychophysical measurements for the detection of a potential analgesic action.…”

A novel radiant heat test for assessing pain threshold in human subjects: Measurement stability

“…Because finger withdrawal latencies remained consistent across test days and within test sessions, this method may be sensitive to acute behavioral or pharmacological manipulations. Radiant heat methodologies have often been criticized as being insensitive to analgesic states (Beecher, 1959;Chapman et aI., 1985;Chapman, Dingman, & Ginzberg, 1965). However, this methodology has been sensitive to glucoseinduced alterations in pain threshold in diabetic animals (Lee & McCarty, 1990.…”