Failure of heterogeneous amyloid‐enhancing factor in geriatric squirrel monkeys (<i><scp>S</scp>aimiri boliviensis</i>)

Murakami, Tomoaki; Ibi, Kanata; Kuraishi, Takeshi; Hattori, Satoshi; Kai, Chieko; Ishiguro, Naotaka; Yanai, Tokuma

doi:10.1111/jmp.12136

Cited by 5 publications

(4 citation statements)

References 19 publications

(21 reference statements)

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“…In our previous study , squirrel monkeys did not develop AA amyloidosis by intravenous administration of bovine AA fibrils under inflammation with silver nitrate. To investigate the effective stimulant, we previously examined the amyloidogenesis of bovine AA fibrils in mice under inflammation by silver nitrate and LPS.…”

Section: Methodsmentioning

confidence: 82%

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Amyloidosis enhancing activity of bovine amyloid A fibrils in C3H/HeN mice and cynomolgus monkeys (Macaca fascicularis)

Tsukawaki

Murakami

Ibi

et al. 2016

J of Medical Primatology

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Section: Methodsmentioning

confidence: 82%

“…We previously reported that administration of bovine AA amyloid fibrils did not enhance AA amyloidosis in geriatric squirrel monkeys . This result suggests that heterogeneous AA amyloidosis may not be easily transmitted to primates.…”

Section: Introductionmentioning

confidence: 85%

Amyloidosis enhancing activity of bovine amyloid A fibrils in C3H/HeN mice and cynomolgus monkeys (Macaca fascicularis)

Tsukawaki

Murakami

Ibi

et al. 2016

J of Medical Primatology

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“…All cases were used in previous experiments, and amyloid deposition had been identified histologically in the brain. 8 After autopsy, brain tissue was fixed in 10% neutral-buffered formalin, coronally sectioned at 5-mm intervals, and embedded in paraffin wax. The experiments were approved by the Animal Care and Use Committee at the Medical Institute of the University of Tokyo and performed according to the guidelines for animal experiments issued by the Medical Institute of the University of Tokyo.…”

Section: Methodsmentioning

confidence: 99%

Label-free autofluorescence and hyperspectral imaging of cerebral amyloid-β lesions in aged squirrel monkeys

Oba,

Ujike,

Ono

et al. 2023

J VET Diagn Invest

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The observation of amyloid-β (Aβ) lesions using autofluorescence in transgenic mice and human Alzheimer disease patients has been reported frequently. However, no reports verify the autofluorescence of spontaneous Aβ amyloidosis in animals, to our knowledge. We validated the autofluorescence of Aβ lesions in spontaneous squirrel monkey cases under label-free conditions; lesions had intense blue-white autofluorescence in fluorescence microscopy using excitation light at 400–440 nm. Thioflavin S staining and immunohistochemistry of the same specimens revealed that this blue-white autofluorescence was derived from Aβ lesions. Hyperspectral analysis of these lesions revealed a characteristic spectrum with bimodal peaks at 440 and 460 nm, as reported for Aβ lesions in mice. Principal component analysis using hyperspectral data specifically separated the Aβ lesions from other autofluorescent substances, such as lipofuscin. A non-labeled and mechanistic detection of Aβ lesions by hyperspectral imaging could provide valuable insights for developing early diagnostic techniques.

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“…Moreover, because of their small size they can be handled easily, trained to perform in behavioral experiments, and have relatively low resource requirements. Studies using the squirrel monkey are prevalent in neuroscience and related fields, including ophthalmology, toxicology, pharmacology, and psychiatry (Merzenich et al 1983; Roe et al 2017; Banks et al 2017; Uno et al 2016; Secci et al 2017; Murakami et al 2014; Myers et al 2007; Wang et al 2013; Wu et al 2016; Chen et al 2015; Chen et al 2003; Chen et al 2017). …”

Section: Introductionmentioning

confidence: 99%

A Web-Based Atlas Combining MRI and Histology of the Squirrel Monkey Brain

et al. 2018

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The squirrel monkey (Saimiri sciureus) is a commonly-used surrogate for humans in biomedical research. In the neuroimaging community, MRI and histological atlases serve as valuable resources for anatomical, physiological, and functional studies of the brain; however, no digital MRI/histology atlas is currently available for the squirrel monkey. This paper describes the construction of a web-based multi-modal atlas of the squirrel monkey brain. The MRI-derived information includes anatomical MRI contrast (i.e., T2-weighted and proton-density-weighted) and diffusion MRI metrics (i.e., fractional anisotropy and mean diffusivity) from data acquired both in vivo and ex vivo on a 9.4 Tesla scanner. The histological images include Nissl and myelin stains, co-registered to the corresponding MRI, allowing identification of cyto- and myelo-architecture. In addition, a bidirectional neuronal tracer, biotinylated dextran amine (BDA) was injected into the primary motor cortex, enabling highly specific identification of regions connected to the injection location. The atlas integrates the results of common image analysis methods including diffusion tensor imaging glyphs, labels of 57 white-matter tracts identified using DTI-tractography, and 18 cortical regions of interest identified from Nissl-revealed cyto-architecture. All data are presented in a common space, and all image types are accessible through a web-based atlas viewer, which allows visualization and interaction of user-selectable contrasts and varying resolutions. By providing an easy to use reference system of anatomical information, our web-accessible multi-contrast atlas forms a rich and convenient resource for comparisons of brain findings across subjects or modalities. The atlas is called the Combined Histology-MRI Integrated Atlas of the Squirrel Monkey (CHIASM). All images are accessible through our web-based viewer ( https://chiasm.vuse.vanderbilt.edu /), and data are available for download at ( https://www.nitrc.org/projects/smatlas/ ).

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Failure of heterogeneous amyloid‐enhancing factor in geriatric squirrel monkeys (Saimiri boliviensis)

Abstract: These results suggest that heterogeneous AA amyloidosis may not be easily transmitted into primates.

Cited by 5 publications

References 19 publications

Amyloidosis enhancing activity of bovine amyloid A fibrils in C3H/HeN mice and cynomolgus monkeys (Macaca fascicularis)

Amyloidosis enhancing activity of bovine amyloid A fibrils in C3H/HeN mice and cynomolgus monkeys (Macaca fascicularis)

Label-free autofluorescence and hyperspectral imaging of cerebral amyloid-β lesions in aged squirrel monkeys

A Web-Based Atlas Combining MRI and Histology of the Squirrel Monkey Brain

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