“…1977;Engleman et al, 1982). Early investigations demonstrated abnormal AMLR in patients with lymphoproliferative and autoimmune diseases (Sakane, Steinberg & Green, 1978;Miyasaka et al, 1980;Engleman et al, 1980), and consequently this assay has gained increasing use in the clinical assessment of immunity. Also, because both effector (cytotoxicity and antibody production) and regulatory (help and suppression) functions are generated during in vitro culture, the AMLR has been used to study interactions between mononuelear eell subsets (Tomanari, 1980;Gatenby, Kotzin & Engleman, 1981;Kotani et al, 1984).…”