Failure of Aureomycin in Treatment of Experimental Leishmaniasis

SYNOPSIS. Intracardial inoculation of 1–10 million L. donovani in 0.1 ml. of ground spleen suspension from an infected animal (hamster) results in a uniform rise of parasite numbers in the untreated animal over the first 8 days after the inoculation. This rise is highly consistent from experiment to experiment. Treatment is accomplished by parenteral injection of a compound for 6 successive days in this time interval, starting 24 hours after inoculation. No known active compound in proper dosage (sodium stibogluconate, pentamidine, fuadin) has failed to show a significant suppression of the expected rise in parasite numbers. No known inactive compound has had any effect on the course of the infection. The dosage‐response curve for the active compounds suggests that the method is a sensitive one. Since it takes only 8 days to complete, it is economical as well.

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Failure of Aureomycin in Treatment of Experimental Leishmaniasis

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The Leishmaniases

The Leishmaniases

Chemotherapy of Leishmaniasis

An Eight‐day Method for Screening Compounds against Leishmania donovani in the Golden Hamster*

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