Failure of attention focus and cognitive control in schizophrenia patients with auditory verbal hallucinations: Evidence from dichotic listening

Hugdahl, Kenneth; Nygård, Merethe; Falkenberg, Liv E.; Kompus, Kristiina; Westerhausen, René; Kroken, Rune A.; Johnsen, Erik; Løberg, Else‐Marie

doi:10.1016/j.schres.2013.04.005

Cited by 48 publications

(38 citation statements)

References 58 publications

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“…Additionally, patients with pronounced hallucinations showed poorer inhibitory top-down control compared to patients with minimal hallucinatory behavior and healthy controls. These results suggest the involvement of impaired auditory top-down control (Bozikas et al, 2014;Hugdahl et al, 2013) and, possibly, affective ToM (Corcoran et al, 1995;Lam et al, 2014) in the formation of hallucinations.…”

Section: Discussionmentioning

confidence: 75%

“…Seidman et al (1993) found an elevated right ear advantage under neuroleptics and a return to the initial lateralization after reduction of medication (not explained by general clinical change). Additionally, in contrast to prior studies (e.g., Hugdahl et al, 2013), in the present study the used index for inhibitory top-down control was adjusted for overall accuracy (see Hirnstein et al, 2014) and working memory load (Penner et al, 2009). Thus, the index was less affected by general and unspecific accuracy performance (e.g., due to individual differences in working memory), which was found to be associated with schizophrenia (see Bozikas et al, 2014;Hugdahl et al, 2003;Løberg et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Schizophrenia symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS; Kay et al, 1987). Patients were divided into a group with "high" (PANSS P3 N 3; n = 7) and a group with "low" hallucinatory behavior (PANSS P3 ≤ 3; n = 13; see Hugdahl et al, 2013). All patients received antipsychotic drugs (typical antipsychotics, n = 1; atypical antipsychotics n = 18; both, n = 1).…”

Section: Participantsmentioning

confidence: 99%

“…The authors claimed that good performance on the Reading the Mind in the Eyes Test may require inhibition of social and personal features (e.g., gender, age, facial features) attributed to the faces (see also Mahy et al, 2014). Since the occurrence of hallucinations was additionally associated with impaired inhibitory top-down control (Bozikas et al, 2014;Ford and Mathalon, 2004;Hugdahl et al, 2013) the current study aimed to investigate the connections between auditory inhibition, affective ToM and the experience of hallucinations in patients with schizophrenia.…”

Section: Introductionmentioning

confidence: 95%

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Auditory top-down control and affective theory of mind in schizophrenia with and without hallucinations

Rominger

Bleier

Fitz

et al. 2016

Schizophrenia Research

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Auditory top-down control and affective theory of mind in schizophrenia with and without hallucinations

Rominger

Bleier

Fitz

et al. 2016

Schizophrenia Research

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“…Multiple studies have hypothesized that the experience of AVHs causes one to become more internally focused on the voices which can, in turn, increase difficulties ignoring the voices or shifting attention away from them in order to better engage in/with the environment (64,65,66). Further, the experience of AVHs carries significant stigma and has been associated with poor outcomes, high level of distress and social isolation (13,67).…”

Section: Discussionmentioning

confidence: 99%

Listening to Schneiderian Voices: A Novel Phenomenological Analysis

et al. 2016

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Background/Aims: This paper reports on analyses designed to elucidate phenomenologicalcharacteristics, content and experience specifically targeting participants with Schneiderian voices conversing/commenting (VC) while exploring differences in clinical presentation and quality of life compared to those with voices not conversing (VNC). Methods: This mixed-method investigation of Schneiderian voices included standardized clinical metrics and exploratory phenomenological interviews designed to elicit in-depth information about the characteristics, content, meaning, and personification of auditory verbal hallucinations. Results: The subjective experience shows a striking pattern of VC, as they are experienced as internal at initial onset and during the longer-term course of illness when compared to VNC. Participants in the VC group were more likely to attribute the origin of their voices to an external source such as God, telepathic communication, or mediumistic sources. VC and VNC were described as characterological entities that were distinct from self (I/we vs. you). We also found an association between VC and the positive, cognitive, and depression symptom profile. However, we did not find a significant group difference in overall quality of life. Conclusions: The clinical portrait of VC is complex, multisensory, and distinct, and suggests a need for further research into the biopsychosocial interface between subjective experience, socioenvironmental constraints, individual psychology, and the biological architecture of intersecting symptoms.

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Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients

et al. 2021

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Objectives Negative emotional valence of auditory verbal hallucinations (AVHs) in schizophrenia can be a source of distress and is considered a strong predictor of illness severity. Previous studies have found glutamate to mediate AVH severity in frontal and temporal brain regions, however, they do not specifically address emotional valence of AVH. The role of glutamate for the experience of negative‐ versus positive emotional valence of AVH is therefore unknown and was investigated in the current study. Methods Using magnetic resonance spectroscopy (MRS), 37 schizophrenia patients had Glx (glutamate+glutamine) measured in the left superior temporal gyrus (STG), and additionally in the anterior cingulate cortex (ACC) and the right STG, or in the left inferior frontal gyrus (IFG). Self‐reported emotional valence in AVH was measured with the Beliefs About Voices Questionnaire (BAVQ‐R). Results Results from linear mixed models showed that negative emotional valence was associated with reduced Glx levels across all four measured brain regions in the frontal and temporal lobe. More specifically, voices that were experienced to be omnipotent (p = 0.04) and that the patients attempted to resist (p = 0.04) were related to lower Glx levels. Follow‐up analysis of the latter showed that voices that evoked emotional resistance (i.e., fear, sadness, anger), rather than behavioral resistance, was a significant predictor of reduced glutamate (p = 0.02). Conclusion The findings could indicate aberrant glutamatergic signaling, or increased NMDA‐receptor hypoactivity in patients who experience their voices to be more emotionally negative. Overall, the study provides support for the glutamate hypothesis of schizophrenia.

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Failure of attention focus and cognitive control in schizophrenia patients with auditory verbal hallucinations: Evidence from dichotic listening

Cited by 48 publications

References 58 publications

Auditory top-down control and affective theory of mind in schizophrenia with and without hallucinations

Auditory top-down control and affective theory of mind in schizophrenia with and without hallucinations

Listening to Schneiderian Voices: A Novel Phenomenological Analysis

Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients

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