Failure of appearance of insulin antibodies in dogs adapted to bovine-porcine insulin

Menzel, R; Knospe, S; Ziegler, M.; Wilke, W; Michael, R.

doi:10.1007/bf01219475

Cited by 6 publications

(1 citation statement)

References 13 publications

(9 reference statements)

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“…From the results discussed and described and the observation of a stimulatory action of insulin antibodies from diabetic mothers on the B-cells of their newborn babies (Amenât et al 1974) we concluded that the preven¬ tion of antibody production should improve diabetes therapy. Hence it is im¬ portan to avoid immunological reactions against insulin for example by using preparations with lower antigenicity (Schlichtkrull et al 1972;Ortved Ander¬ sen 1975), by modification of the insulin dose and the method of administra¬ tion (Menzel et al 1971), and/or by induction of an immune tolerance, which has already been successful in animals (Menzel et al 1971;Jansen 1971).…”

Section: Discussionmentioning

confidence: 98%

Enhancement of Glucose-Stimulated Insulin Secretion From Isolated Rat Pancreatic Islets by Human Insulin Antibodies

Hahn

Menzel

Gottschling

et al. 1976

Acta Endocrinologica

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Isolated pancreatic rat islets incubated in vitro were used as a bioassay system for investigating the influence of human insulin antibodies on insulin secretion. Serum samples with different titres of insulin antibodies were obtained from juvenile diabetics after various periods of insulin therapy. The insulin secretion of isolated islets is enhanced by insulin antibodies and positively correlated to the measured antibody titres in serum.In agreement with Cahill (1973) and Block et al. (1973) we are of the opinion that the initial remission phase may play an important role in the prognosis of diabetes mellitus. This period is characterized by a recovered stabilization of diabetes due to an improved insulin secretion (Blaim 8c KielanowskaStunieka 1971;Menzel et al. 1972;Block et al. 1973). After different time periods the functional capacity of B-cells is exhausted and a more or less severe juvenile diabetes results. At present some possibilities for the final impairment of B-cell function are under discussion. Firstly it seems possible that the pathogenetic process continues to disturb the B-cells. Secondly the B-cell exhaustion could also be influenced by immunological reactions (cellu¬ lar and humoral) against exogenous insulin. Even if there is no strong cor¬ relation between the insulin-antibody titres and the termination of the initial remission phase, it is remarkable that under the commonly used insulin

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Section: Discussionmentioning

confidence: 98%