Failure of adjunctive minocycline‐HCI to eliminate oral Actinobacillus actinomycetemcomitans

Abstract

Considerable problems have been reported in the eradication of Actinobacillus actinomycetemcomitans from periodontal sites. The present communication describes the 2-year results of a comprehensive combined mechanical/surgical and adjunctive minocycline (200 mg/day for 3 and another 2 weeks) treatment regimen in 28 patients with A. actinomycetemcomitans-associated periodontitis. Elimination of A. actinomycetemcomitans at periodontal sites was a prerequisite for gain of clinical attachment of > or = 2 mm or decrease of probing depth to < or = 4 mm after subgingival scaling plus minocycline (p < 0.01). Whereas 2 years after active treatment A. actinomycetemcomitans could not be detected at monitored sites in 23 patients, the organism was found on buccal mucosa and in saliva in 17 and 12 cases, respectively. One or 2 years after periodontal surgery, there was a significant association between log10-numbers of A. actinomycetemcomitans in buccal samples and numbers of residual pockets of > or = 7 mm as well as gingival sites with overt gingivitis (R2 = 0.687, p < 0.001). Present results indicate failure of an even prolonged administration of adjunctive minocycline to eliminate oral A. actinomycetemcomitans in most cases of A. actinomycetemcomitans-associated periodontitis.

Effect of a controlled release device containing minocycline microspheres on the treatment of chronic periodontitis: A comparative study

“…Thus, when the gingival status was compared between Group A and Group B, a significant improvement was observed on day 30, day 90, and day 180 in the test sites [Graph 2]. This is consistent with the findings of the studies conducted by Muller et al .,[17] Vansteenberghe et al .,[10] Saito et al .,[12] Jones et al .,[13] Timmerman et al .,[14] Radvar et al ,[18] Hagiwara et al .,[15] Vansteenberghe et al .,[16] and Kinane et al . [19]…”

Antimicrobial Advances in Treating Periodontal Diseases

“…Local therapy presupposes that the infection is limited to the clinically diagnosed lesion. Bacteria typically associated with periodontal lesions can, however, also be detected in clinically unaffected regions of the dentition [2, 3] and non-dental sites, such as the dorsum of the tongue or tonsillar crypts [4][5][6][7][8]. Systemic adverse drug reactions, on the other hand, are a greater concern and more likely to occur if drugs are distributed via the systemic route.…”

Comparison of two different microbiological test kits for detection of periodontal pathogens

“…Identification of these microorganisms in periodontal patients with the help of commercially available gene probe tests has become a clinical valuable tool in treatment planning and in the selection of adjunctive antibiotics. In patients who tested positive for A.a., it could be shown that the mechanical removal of the subgingival biofilm alone did not ensure a reliable and predictable treatment outcome [5][6][7]. Furthermore, it was shown that A.a. plays a crucial role in the aetiology of severe chronic periodontitis, aggressive periodontitis [8][9][10] and periodontitis as a manifestation of Papillon Lefèvre syndrome [11].…”