In order to facilitate and advance safety management within the chemical industry and to further improve the theoretical foundation of safety culture in the chemical industry; this study systematically investigates the generation of safety culture and the practical investment directions in the chemical industry using methods of logical analysis and literature analysis. Firstly, a definition of safety culture generation in the chemical industry is proposed. Based on this definition, six factors influencing safety culture generation are identified: chemical industry employees, safety production needs, safety hazards, empirical methods, response results, and employees' safety assurance capabilities. Furthermore, five approaches and two motivations of safety culture generation in the chemical industry are delineated. By sifting through and analyzing pertinent literature, this study sums up four kinds of practice forms and investment directions: scientific theory research, scientific technology application, formulate rules and regulations, and scientific popularization. The findings reveal that the process of safety culture generation in the chemical industry can be categorized into three stages: demand generation, ability/awareness generation, and system generation. The generation mechanisms encompass six factors, five approaches, two motivations, and four practical forms and investment directions.